United States securities and exchange commission logo May 15, 2023 Gregory Schiffman Chief Financial Officer Absci Corp 18105 SE Mill Plain Blvd Vancouver, Washington 98683 Re: Absci Corp Form 10-K for the Fiscal Year End December 31, 2022 Filed March 30, 2023 File No. 001-40646 Dear Gregory Schiffman: We have limited our review of your filing to the financial statements and related disclosures and have the following comment. In our comment, we may ask you to provide us with information so we may better understand your disclosure. Please respond to this comment within ten business days by providing the requested information or advise us as soon as possible when you will respond. If you do not believe our comment applies to your facts and circumstances, please tell us why in your response. After reviewing your response to this comment, we may have additional comments. Form 10-K for the Fiscal Year Ended December 31, 2022 Item 9A. Controls and Procedures, page 116 1. Please amend your filing to provide management s conclusion regarding the effectiveness of the company s disclosure controls and procedures as of the end of the period covered by this report in accordance with Item 307 of Regulation S-K. In closing, we remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Gregory Schiffman Absci Corp May 15, 2023 Page 2 You may contact Julie Sherman at (202) 551-3640 or Brian Cascio, Accounting Branch Chief, at (202) 551-3676 with any questions. Sincerely, FirstName LastNameGregory Schiffman Division of Corporation Finance Comapany NameAbsci Corp Office of Industrial Applications and May 15, 2023 Page 2 Services FirstName LastName