0001628280-22-006925 | 10-K | XBRL Viewer

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Organization and nature of operations	12 Months Ended
Organization and nature of operations	Dec. 31, 2021
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Organization and nature of operations	Organization and nature of operations Absci Corporation (the “Company”) has developed an integrated drug creation platform (the “Integrated Drug Creation Platform”) by merging deep learning artificial intelligence and synthetic biology. The Integrated Drug Creation Platform enables the creation of biologics by unifying the drug discovery and cell line development processes into one process. The Company was organized in the State of Oregon in August 2011 as a limited liability company and converted to a limited liability company (“LLC”) in Delaware in April 2016. In October 2020, the Company converted from a Delaware LLC to a Delaware corporation (the “LLC Conversion”). The Company’s headquarters are located in Vancouver, Washington. Authorized shares of common stock In June 2021, the Company’s board of directors (the “Board”) and stockholders increased the number of authorized shares of common stock to 78,320,000. Initial Public Offering In July 2021, we completed our initial public offering (IPO) and issued 14.4 million shares of our common stock, including 1.9 million shares pursuant to the full exercise of the underwriters’ option to purchase additional shares, at a price of $16.00 per share and received net proceeds of $210.1 million from the IPO. Immediately prior to the completion of the IPO, all shares of redeemable convertible preferred stock then outstanding were converted into 46.3 million shares of common stock and all convertible notes issued in March 2021 were converted into 9.7 million shares of common stock. Amendments to Certificate of Incorporation or Bylaws In connection with the consummation of the IPO, the Company filed an amended and restated certificate of incorporation (the “Restated Certificate”) with the Secretary of State of the State of Delaware. The Board and stockholders previously approved the Restated Certificate to be filed in connection with, and to be effective upon, the consummation of the IPO. The Restated Certificate amended and restated the Company’s existing amended and restated certificate of incorporation, as amended, in its entirety to, among other things: (i) authorize 500,000,000 shares of common stock; (ii) eliminate all references to the previously-existing series of preferred stock; (iii) authorize 10,000,000 shares of undesignated preferred stock that may be issued from time to time by the Board in one or more series; (iv) establish a classified board divided into three classes, with each class serving staggered three-year terms and (v) require the approval of holders of at least 75% of the voting power of the Company’s outstanding shares of voting stock to amend or repeal certain provisions of the Restated Certificate. Stock split On July 16, 2021, the Board and stockholders approved an amendment to the Company’s amended and restated certificate of incorporation to effect a forward stock split of the Company’s issued and outstanding common stock at a 3.3031-to-1 ratio, which was effected on July 19, 2021. The par value and convertible preferred stock were not adjusted as a result of the forward stock split. All issued and outstanding common stock, options to purchase common stock and units, and per share and unit amounts contained in the financial statements have been retroactively adjusted to reflect the forward stock split for all periods presented. The financial statements have also been retroactively adjusted to reflect a proportional adjustment to the conversion ratio for each series of preferred stock that was effected in connection with the forward stock split. LLC Conversion In conjunction with the LLC Conversion as of October 15, 2020, (i) all of the Company’s outstanding common units converted on a 1-for-1 basis into shares of common stock, par value $0.0001; and (ii) all of the Company’s outstanding redeemable preferred units converted on a 1-for-1 basis into shares of redeemable convertible preferred stock, par value $0.0001. Prior to the LLC Conversion, the Company had issued incentive units to certain employees, directors, and consultants. The outstanding vested incentive units converted on a net issuance basis into shares of common stock and the outstanding unvested incentive units converted on a net issuance basis into restricted common stock. All vesting provisions remained the same following the LLC Conversion. See Note 10: Stock-based compensation for further discussion of the LLC Conversion’s impact on the Company’s stock-based compensation plans.

Fair Value Measurements - Narrative (Details) - $ / shares	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2018	Jun. 30, 2018	Dec. 31, 2016
Line of Credit \| LSA
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis
Liquidity event fee (percent)		3.50%	3.50%
Series A-1
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis
Class of warrant or right, number of securities called by warrants or rights (in shares)				93,007
Class of warrant or right, exercise price of warrants or rights (usd per share)				$ 1
Common Stock \| Affiliated Entity
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis
Issuance of shares upon warrant exercise (in shares)	307,211

Income Taxes - Schedule of Unrecognized Tax Benefits (Details) $ in Thousands	12 Months Ended
	Dec. 31, 2021 USD ($)
Income Tax Disclosure [Abstract]
Balance at January 1	$ 0
Additions Based On Tax Positions Related to Current Year	698
Balance at December 31	$ 698

CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020
Cash Flows From Operating Activities
Net Income (Loss) Attributable to Parent	$ (100,960)	$ (14,353)
Adjustments to reconcile net loss to net cash used in operating activities
Depreciation and amortization	6,654	1,131
Deferred income taxes	(8,901)	0
Share-based compensation	10,608	420
Change in fair value of convertible promissory notes	30,722	0
Gain on extinguishment of loan payable	(636)	0
Loss on disposal and impairment of assets	948	363
Foreign exchange transaction losses (gains)	(11)	0
Preferred stock warrant liability expense	4,124	461
Changes in operating assets and liabilities:
Receivables under development arrangements	230	(1,372)
Prepaid expenses and other current assets	(7,636)	(1,434)
Operating lease right-of-use assets and liabilities	3,256	93
Other long-term assets	126	(85)
Accounts payable	1,574	903
Accrued expenses and other liabilities	581	1,053
Deferred revenue	(1,277)	1,850
Net cash used in operating activities	(60,598)	(10,970)
Cash Flows From Investing Activities
Purchases of property and equipment	(38,047)	(2,181)
Acquisitions, net of cash acquired	(28,130)	0
Investment in equity securities	(1,200)	0
Proceeds from sales of property and equipment	0	10
Net cash used in investing activities	(67,377)	(2,171)
Cash Flows From Financing Activities
Proceeds from issuance of redeemable convertible preferred units and stock, net of issuance costs	4,944	69,334
Proceeds from issuance of long-term debt	0	2,598
Proceeds from notes payable	0	632
Principal payments on long-term debt	(1,600)	(500)
Principal payments on finance lease obligations	(2,547)	(1,091)
Proceeds from issuance of common stock, net of issuance costs	210,396	0
Proceeds from issuance of convertible promissory notes	125,000	0
Net cash provided by financing activities	336,193	70,973
Net increase (decrease) in cash, cash equivalents, and restricted cash	208,218	57,832
Cash, cash equivalents and restricted cash - Beginning of year	71,708	13,876
Cash, cash equivalents, and restricted cash - End of period	279,926	71,708
Supplemental Disclosure of Cash Flow Information
Cash paid during the period for interest	652	508
Supplemental Disclosure of Non-Cash Investing and Financing Activities
Property and equipment purchased under finance lease	4,313	3,988
Right-of-use assets obtained in exchange for operating lease obligation	3,330	3,114
Cash paid for amounts included in the measurement of operating lease liabilities	1,631	422
Property and equipment purchases included in accounts payable	5,565	945
Increase in redemption value of convertible preferred stock	$ 0	$ 34,336

Long-term debt and other borrowings (Tables)

12 Months Ended

Dec. 31, 2021

Debt Disclosure [Abstract]

Schedule of Maturities of Long-term Debt

Future maturities of the amounts outstanding under the LSA as of December 31, 2021 are as follows (in thousands):



Years ending December 31:
2022	$	2,400
2023	1,150
2024	—
2025	—
2026	—
Total principal, including final fee	3,550
Less: amount representing debt discounts and issuance costs	(26)
Total long-term debt	$	3,524

Long-term debt and other borrowings (Details)	1 Months Ended			3 Months Ended	12 Months Ended
Long-term debt and other borrowings (Details)	Mar. 31, 2021 USD ($) shares	Feb. 28, 2021 USD ($)	May 31, 2020 USD ($)	Mar. 31, 2018 USD ($)	Dec. 31, 2021 USD ($)	Dec. 31, 2020 USD ($)	May 11, 2022	Jul. 31, 2021 $ / shares	Jun. 30, 2021	Jun. 30, 2019	Mar. 31, 2019 USD ($)	Dec. 31, 2018	Jun. 30, 2018 USD ($) tranche
Debt Instrument
Proceeds from issuance of long-term debt					$ 0	$ 2,598,000
Total long-term debt					3,524,000
Proceeds from notes payable					0	632,000
Gain on extinguishment of loan payable					$ 636,000	$ 0
IPO
Debt Instrument
Issuance price (usd per share) \| $ / shares								$ 16.00
CARES Act \| Loans Payable
Debt Instrument
Interest rate (percent)			1.00%
Proceeds from notes payable			$ 600,000
Debt instrument term (years)			2 years
Gain on extinguishment of loan payable		$ 600,000
2021 Notes \| Convertible promissory notes
Debt Instrument
Interest rate (percent)	6.00%
Principal amount	$ 125,000,000
Discount on offering price (percent)									18.00%
Shares issued upon conversion of convertible debt (shares) \| shares	9,732,593
Line of Credit \| LSA
Debt Instrument
Number of tranches \| tranche													3
Maximum borrowing capacity													$ 3,000,000
Proceeds from issuance of long-term debt				$ 300,000
Interest rate (percent)													6.00%
Prepayment premium (percent)		1.00%
Final payment percentage as a portion of principal amount funded (percent)										3.00%
Liquidity event fee (percent)												3.50%	3.50%
Debt covenant, required percentage of cash on had based on projected revenue					80.00%
Total long-term debt					$ 3,400,000
Line of Credit \| LSA \| Forecast
Debt Instrument
Prepayment premium (percent)							0.00%
Line of Credit \| LSA, First Amendment
Debt Instrument
Maximum borrowing capacity											$ 3,000,000
Line of Credit \| LSA, Second Amendment
Debt Instrument
Maximum borrowing capacity			$ 5,000,000

Fair Value Measurements - Fair Value Using Significant Unobservable Inputs (Level 3) (Details) - Fair Value, Recurring $ in Thousands	12 Months Ended
	Dec. 31, 2021 USD ($)
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation
Beginning balance	$ 720
Fair at issuance	137,000
Change in the fair value	35,020
Conversion of instrument	(160,740)
Ending balance	12,000
Fee in-lieu of warrant
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation
Beginning balance	22
Fair at issuance	0
Change in the fair value	174
Conversion of instrument	(196)
Ending balance	0
Convertible promissory notes
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation
Beginning balance	0
Fair at issuance	125,000
Change in the fair value	30,722
Conversion of instrument	(155,722)
Ending balance	0
Preferred stock warrant liability
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation
Beginning balance	698
Fair at issuance	0
Change in the fair value	4,124
Conversion of instrument	(4,822)
Ending balance	0
Contingent consideration
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation
Beginning balance	0
Fair at issuance	12,000
Change in the fair value	0
Conversion of instrument	0
Ending balance	$ 12,000

Stock-based compensation (Tables)

12 Months Ended

Dec. 31, 2021

Share-based Payment Arrangement [Abstract]

Schedule of Allocation of Share based Compensation

Total stock-based compensation expense related to all of the Company’s stock-based awards was recorded in the consolidated statements of operations and comprehensive loss as follows (in thousands):



	For the Years Ended December 31,
		2021		2020
Research and development		4,637		188
Selling, general and administrative		5,971		232
Total stock-based compensation expense		$	10,608	$	420

Schedule of Nonvested Share Activity

Activity for the restricted shares is shown below:


			Number of shares
Unvested as of December 31, 2020			1,111,642
Granted			2,441,129
Vested			(967,101)
Unvested as of December 31, 2021			2,585,670

Activity for the phantom units is shown below:


	Number of Units	Weighted Average Strike Price
Unvested as of December 31, 2020	1,202,435	$	0.47
Granted	—	—
Vested	—	—
Exchange of Phantom Units for Cash Payment Rights, SARs, and/or Stock Options	(1,202,435)	$	0.47
Unvested as of December 31, 2021	—	$	—

Schedule of Stock Option Activity

Activity for stock options is shown below:


	Number of Options	Weighted Average Exercise Price per Share		Weighted Average Remaining Contractual Term (in years)	Aggregate Intrinsic Value (in thousands $)
Outstanding at December 31, 2020	1,706,339	$	1.10	9.8	$	780
Granted	7,386,667	4.01			—
Exercised	(153,416)	1.10
Canceled/ Forfeited	(1,182,189)	2.14			—
Outstanding at December 31, 2021	7,757,401	3.72		9.2	40,939
Exercisable at December 31, 2021	1,675,979	$	1.13	9.0	$	11,851
Vested and expected to vest as of December 31, 2021	7,757,401			9.2	$	40,939

Schedule of Determination of Fair Value

The estimated grant-date fair value of all the Company’s stock options was calculated using the Black-Scholes option pricing model, based on the following assumptions:



	For the Years Ended December 31,
	2021	2020
Expected term (in years)	3.5-6.1	2.0-6.0
Volatility	45%-47%	45%-85%
Risk-free interest rate	0.3%-1.5%	0.1%-1.6%
Dividend Yield	—%	—%

Acquisitions - Fair Value of Assets and Liabilities Acquired (Details) - USD ($) $ in Thousands	Dec. 31, 2021	Jun. 04, 2021	Jan. 31, 2021	Dec. 31, 2020
Current assets:
Goodwill	$ 21,335			$ 0
Denovium
Current assets:
Cash and cash equivalents			$ 158
Accounts receivable			59
Other current assets			1
Intangible assets			2,507
Goodwill			1,055
TOTAL ASSETS			3,780
Current liabilities:
Accounts payable and accrued expenses			109
Deferred tax, net			633
TOTAL LIABILITIES			742
Fair value of net assets acquired and liabilities assumed			$ 3,038
Totient
Current assets:
Cash and cash equivalents		$ 1,751
Prepaid expenses and other current assets		189
Total current assets		1,940
Operating lease right-of-use assets		266
Property and equipment, net		118
Intangible assets		54,600
Goodwill		20,280
Other long-term assets		23
TOTAL ASSETS		77,227
Current liabilities:
Accounts payable		78
Accrued expenses		6,588
Operating lease obligations, current		122
Total current liabilities		6,788
Operating lease obligations - net of current portion		144
Deferred tax, net		9,012
Other long-term liabilities		24
TOTAL LIABILITIES		15,968
Fair value of net assets acquired and liabilities assumed		$ 61,259

Stock-based compensation - Determination of Fair Value (Details)	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020
Fair Value Assumptions and Methodology
Risk-free interest rate, minimum	0.30%	0.10%
Risk-free interest rate, maximum	1.50%	1.60%
Dividend Yield	0.00%	0.00%
Minimum
Fair Value Assumptions and Methodology
Expected term (in years)	3 years 6 months	2 years
Volatility	45.00%	45.00%
Maximum
Fair Value Assumptions and Methodology
Expected term (in years)	6 years 1 month 6 days	6 years
Volatility	47.00%	85.00%

Income Taxes - Narratives (Details) - USD ($)	12 Months Ended
Income Taxes - Narratives (Details) - USD ($)	Dec. 31, 2021	Dec. 31, 2020
Income Tax Disclosure [Abstract]
Deferred tax assets, operating loss carryforwards, domestic	$ 86,300,000
Deferred tax assets, operating loss carryforwards, state and local	74,900,000
Deferred tax assets, tax credit carryforwards, research	1,400,000
Valuation allowance increased	10,000,000	$ 500,000
Unrecognized tax benefits	698,000	0
Income tax interest and penalties payment	$ 0	$ 0

Property and equipment, net (Tables)

12 Months Ended

Dec. 31, 2021

Property, Plant and Equipment [Abstract]

Schedule of Components of Property and Equipment

Property and equipment as of December 31, 2021 and 2020 consists of the following (in thousands):



	December 31,		December 31,
	2021		2020
Construction in progress	$	933	$	—
Lab Equipment	27,776		8,578
Software	311		188
Furniture, Fixtures and Other	4,804		472
Leasehold Improvements	24,671		2,016
Total Cost	58,495		11,254
Less accumulated depreciation and amortization	(6,381)		(2,345)
Property and equipment, net	$	52,114	$	8,909

Acquisitions - Consideration (Details) $ in Thousands		1 Months Ended
Acquisitions - Consideration (Details) $ in Thousands	Jun. 04, 2021 USD ($) installment shares	Jan. 31, 2021 USD ($) shares
Denovium
Business Combination, Consideration Transferred
Cash consideration		$ 2,670
Equity consideration		368
Total purchase consideration		$ 3,038
Denovium \| Common Stock
Business Combination, Consideration Transferred
Shares issued as consideration (shares) \| shares		1,010,296
Totient
Business Combination, Consideration Transferred
Cash consideration	$ 40,000
Equity consideration	13,891
Estimated cash payment to Totient stockholders	35,368
Estimated cash payment contingent on achieving specified milestone	12,000
Total purchase consideration	61,259
Minimum contingent proceeds due from potential trigger event	2,000
Totient \| Individual Contract
Business Combination, Consideration Transferred
Minimum contingent proceeds due from potential trigger event	$ 1,000
Totient \| Common Stock
Business Combination, Consideration Transferred
Shares issued as consideration (shares) \| shares	2,212,208
Totient \| Vest On Closing \| Common Stock
Business Combination, Consideration Transferred
Milestone consideration (shares) \| shares	1,282,747
Totient \| Share Vesting Based On Service
Business Combination, Consideration Transferred
Vesting period	2 years 6 months
Totient \| Share Vesting Based On Service \| Common Stock
Business Combination, Consideration Transferred
Milestone consideration (shares) \| shares	929,461
Vesting rate (months)	6 months
Vesting installments \| installment	5

Summary of significant accounting policies - Property and equipment, net (Details) - USD ($)	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020
Property, Plant and Equipment
Operating lease, impairment loss	$ 600,000
Impairment of long lived assets		$ 0
Leasehold Improvements
Property, Plant and Equipment
Impairment of long lived assets	$ 300,000
Minimum
Property, Plant and Equipment
Useful life (years)	3 years
Maximum
Property, Plant and Equipment
Useful life (years)	7 years

Property and equipment, net

12 Months Ended

Dec. 31, 2021

Property, Plant and Equipment [Abstract]

Property and equipment, net

Property and equipment as of December 31, 2021 and 2020 consists of the following (in thousands):



	December 31,		December 31,
	2021		2020
Construction in progress	$	933	$	—
Lab Equipment	27,776		8,578
Software	311		188
Furniture, Fixtures and Other	4,804		472
Leasehold Improvements	24,671		2,016
Total Cost	58,495		11,254
Less accumulated depreciation and amortization	(6,381)		(2,345)
Property and equipment, net	$	52,114	$	8,909

Depreciation expense was $4.5 million and $1.1 million for the years ended December 31, 2021 and 2020, respectively.

Goodwill and Intangibles, net - Narrative (Details)	12 Months Ended
Goodwill and Intangibles, net - Narrative (Details)	Dec. 31, 2021 USD ($)
Goodwill and Intangible Assets Disclosure [Abstract]
Goodwill, impaired, accumulated impairment loss	$ 0
Amortization expense related to intangible assets	$ 2,100,000

STATEMENTS OF CHANGES IN REDEEMABLE CONVERTIBLE PREFERRED STOCK AND UNITS AND OTHER STOCKHOLDERS’ AND MEMBERS’ DEFICIT - USD ($) $ in Thousands	Total	IPO	Redeemable Convertible Preferred Stock [Member]	Preferred stock Redeemable Convertible Preferred Units	Preferred stock Redeemable Convertible Preferred Stock [Member]	Common Units	Common Stock	Common Stock IPO	Additional Paid-In Capital	Additional Paid-In Capital IPO	Accumulated Deficit	Accumulated Other Comprehensive Income (Loss)
Increase (Decrease) in Stockholders' Equity
Beginning balance, shares							0
Beginning balance at Dec. 31, 2019				$ 52,763	$ 0
Beginning balance, shares at Dec. 31, 2019				9,964,572	0
Increase (Decrease) in Temporary Equity
Issuance of preferred units net of issuance costs				$ 4,625	$ 64,709
Issuance of preferred units net of issuance costs, shares				473,952	3,313,519
Increase in preferred unit redemption value				$ 34,336
Conversion of redeemable convertible preferred stock				$ (91,724)	$ 91,724
Conversion of preferred stock, shares				(10,438,524)	10,438,524
Ending balance at Dec. 31, 2020				$ 0	$ 156,433
Ending balance, shares at Dec. 31, 2020			13,752,043	0	13,752,043
Beginning balance at Dec. 31, 2019	$ (41,159)					$ 2	$ 0		$ 215		$ (41,376)	$ 0
Beginning balance, units at Dec. 31, 2019						15,215,724
Increase (Decrease) in Stockholders' Equity
Increase in preferred unit redemption value	(34,336)										(34,336)
Conversion of preferred and common units to shares	0					$ (2)	$ 2
Conversion of preferred and common units to shares, shares						(15,215,724)	15,215,724
Issuance of restricted stock, shares							2,671,907
APIC, Share-based Payment Arrangement, Increase for Cost Recognition	420								420
Net Income (Loss) Attributable to Parent	(14,353)										(14,353)
Ending balance at Dec. 31, 2020	(89,428)					$ 0	$ 2		635		(90,065)	0
Ending balance, units at Dec. 31, 2020						0
Ending balance, shares at Dec. 31, 2020							17,887,631
Increase (Decrease) in Stockholders' Equity
Beginning balance, shares							17,887,631
Issuance of preferred units net of issuance costs					$ 4,944
Issuance of preferred units net of issuance costs, shares					254,886
Conversion of redeemable convertible preferred stock					$ (161,377)
Conversion of preferred stock, shares					(14,006,929)
Ending balance at Dec. 31, 2021				$ 0	$ 0
Ending balance, shares at Dec. 31, 2021				0	0
Increase (Decrease) in Stockholders' Equity
Issuance of restricted stock, shares							703,425
Share-Based Compensation Arrangement By Share-Based Payment Award, Options, Grants In Period, Net Of Forfeitures	169								169
Issuance of shares upon option exercise, shares							153,416
APIC, Share-based Payment Arrangement, Increase for Cost Recognition	9,932								9,932
Issuance of shares in acquisition	14,259								14,259
Issuance of shares in acquisition, shares							3,222,504
Issuance of stock, net of issuance costs		$ 210,134						$ 1		$ 210,133
Issuance of stock, net of issuance costs, shares								14,375,000
Adjustments to Additional Paid in Capital, Equity Component of Convertible Debt	155,722						$ 1		155,721
Conversion of convertible note, shares							9,732,593
Stock Issued During Period, Value, Conversion of Convertible Securities	161,377						$ 5		161,372
Conversion of redeemable convertible preferred stock (in shares)							46,266,256
Adjustments to Additional Paid in Capital, Warrant Issued	4,822								4,822
Issuance Of Shares Upon Warrant Exercise, Value	93								93
Issuance of shares upon warrant exercise (in shares)							307,211
Foreign currency translation adjustments	(13)											(13)
Net Income (Loss) Attributable to Parent	(100,960)										(100,960)
Ending balance at Dec. 31, 2021	$ 366,107					$ 0	$ 9		$ 557,136		$ (191,025)	$ (13)
Ending balance, units at Dec. 31, 2021						0
Ending balance, shares at Dec. 31, 2021							92,648,036
Increase (Decrease) in Stockholders' Equity
Beginning balance, shares							92,648,036

Summary of significant accounting policies - Concentration Risk (Details)	12 Months Ended
	Dec. 31, 2021 partner vendor	Dec. 31, 2020 partner
Equipment Supplier \| Supplier Concentration Risk \| Two Vendors
Concentration Risk
Number of vendors \| vendor	2
Technology development revenue \| Revenue from Contract with Customer Benchmark \| Customer Concentration Risk
Concentration Risk
Concentration risk percentage	73.00%	77.00%
Number of partners (partner)	2	2
Technology development revenue \| Accounts Receivable \| Customer Concentration Risk
Concentration Risk
Concentration risk percentage	84.00%	93.00%
Number of partners (partner)	4	1

Leases - Weighted Average Remaining Lease Term and Discount Rate (Details)	Dec. 31, 2021	Dec. 31, 2020
Weighted average remaining lease term (in years)
Operating leases	6 years	4 years 10 months 24 days
Finance leases	2 years 2 months 12 days	3 years
Weighted average discount rate
Operating leases	8.00%	8.00%
Finance leases	7.00%	7.00%

Leases (Tables)

12 Months Ended

Dec. 31, 2021

Leases [Abstract]

Schedule of Lease Details

The components of lease expense were as follows (in thousands):



	For the Years Ended December 31,
	2021		2020
Operating lease cost	1,780		526
Variable lease cost	425		166
Short-term lease cost	155		18
	$	2,360	$	710

Additional information related to the Company’s leases as of December 31, 2021 and 2020 is as follows:


	December 31, 2021		December 31, 2020
Weighted average remaining lease term (in years)
Operating leases	6		4.9
Finance leases	2.2		3.0

Weighted average discount rate
Operating leases	8	%	8	%
Finance leases	7	%	7	%

Future Undiscounted Lease Payment - Operating Lease

Future undiscounted lease payments for the Company’s lease liabilities as of December 31, 2021 are as follows (in thousands):


	Operating leases		Finance leases
2022	$	2,294	$	3,127
2023	2,285		2,477
2024	2,135		968
2025	1,873		86
2026	1,929		—
Thereafter	2,821		—
Total future lease payments	13,337		6,658
Less: Imputed interest	(2,832)		(642)
Less: Lease incentive	(34)		—
Present value of lease liabilities	$	10,471	$	6,016

Future Undiscounted Lease Payment - Finance Lease

Future undiscounted lease payments for the Company’s lease liabilities as of December 31, 2021 are as follows (in thousands):


	Operating leases		Finance leases
2022	$	2,294	$	3,127
2023	2,285		2,477
2024	2,135		968
2025	1,873		86
2026	1,929		—
Thereafter	2,821		—
Total future lease payments	13,337		6,658
Less: Imputed interest	(2,832)		(642)
Less: Lease incentive	(34)		—
Present value of lease liabilities	$	10,471	$	6,016

Acquisitions (Tables)

12 Months Ended

Dec. 31, 2021

Business Combination and Asset Acquisition [Abstract]

Schedule of Consideration Transferred

Pursuant to the terms of the agreement, the Company acquired all outstanding equity of Denovium for estimated total consideration of $3.0 million, which consists of (in thousands):



Cash consideration	$	2,670
Equity consideration	368
Total purchase consideration	$	3,038

The following table summarizes the preliminary purchase price (in thousands):



Estimated cash payment to Totient stockholders	$	35,368	(i)
Estimated stock payment to Totient stockholders	13,891		(ii)
Estimated cash payment contingent on achieving specified milestone	12,000		(iii)
Total	$	61,259

(i)Pursuant to the merger agreement, the initial purchase price includes $40.0 million of cash adjusted for the agreed upon working capital value which includes the payment of Totient’s transaction and other expenses as well as payments to Totient stock option holders for the cancellation and extinguishment of Totient stock options.

(ii)Pursuant to the merger agreement, 2,212,208 shares of common stock issued in payment to Totient stockholders with 1,282,747 vesting immediately and therefore included in the purchase price consideration. The remaining 929,461 shares will vest ratably, every six months over 5 equal installments of a 2.5 years service period and will be expensed over the service period. These shares are subject to a stock restriction agreement that requires certain key Totient executives to maintain a continued service relationship throughout the service period.

(iii)Represents the estimated fair value of the contingent consideration that is payable upon the achievement of the milestone of (i) Absci’s entering into one or more definitive commercialization agreements, or technology partnering or licensing agreements, or collaboration agreements, with third parties using, or related to, Totient’s technology, a target discovered or identified by using Totient’s technology, or a peptide, protein complex or amino acid sequence assembled using Totient’s technology, including any Totient product or enabled product, pursuant to which (a) Absci is entitled to receive at least $2.0 million in aggregate upfront cash or equity payments (provided, that the minimum upfront payment under any individual agreement shall be $1.0 million and (b) an option for a license or a license or similar right is granted to the third party; or (ii) first commercial sale of a Totient product or enabled product. The fair value estimate is based on a probability-weighted approach and will be updated as we obtain more information. The $12.0 million of contingent consideration is included in Other long-term liabilities on the consolidated balance sheet as of December 31, 2021.

Schedule of Assets and Liabilities Acquired

The following table summarizes the allocation of the purchase consideration to the fair value of the assets acquired and liabilities assumed (in thousands):



Cash and cash equivalents	$	158
Accounts receivable	59
Other current assets	1
Intangible assets	2,507
Goodwill	1,055
TOTAL ASSETS	3,780
Accounts payable and accrued expenses	109
Deferred tax liability	633
TOTAL LIABILITIES	742
Fair value of net assets acquired and liabilities assumed	$	3,038

The following table summarizes the allocation of the estimated consideration to the identifiable assets and liabilities acquired by us as of June 4, 2021 (in thousands).



Current assets:
Cash and cash equivalents	$	1,751
Prepaid expenses and other current assets	189
Total current assets	1,940
Operating lease right-of-use assets	266
Property and equipment, net	118
Goodwill	20,280		(i)
Intangible assets	54,600		(ii)
Other long-term assets	23
TOTAL ASSETS	77,227
Current liabilities:
Accounts payable	78
Accrued expenses	6,588
Operating lease obligations, current	122
Total current liabilities	6,788
Operating lease obligations - net of current portion	144
Deferred tax, net	9,012
Other long-term liabilities	24
TOTAL LIABILITIES	15,968
Fair value of net assets acquired and liabilities assumed	$	61,259

(i)Goodwill represents the excess of the estimated purchase price over the estimated fair value of Totient’s identifiable assets acquired and liabilities assumed. Goodwill also reflects the requirement to record deferred tax balances for the difference between the assigned values and the tax bases of assets acquired and liabilities assumed in the business combination. Goodwill is not deductible for tax purposes.

(ii)The estimated fair value of and useful lives of the intangible assets acquired is as follows:

Schedule Estimated Fair Values of the Identified Intangible Assets

The following table reflects the fair values of the identified intangible assets of Denovium and their respective weighted-average estimated amortization periods.



	Estimated Fair Value (in thousands)		Estimated Amortization Period (years)
Denovium Engine	$	2,507	5
	$	2,507


	Estimated fair value (in thousands)(i)		Estimated useful lives (in years)(ii)
Monoclonal antibody library	$	46,300	20
Developed software platform and the related methods patents	8,300		15
Total	$	54,600

(i)The estimated fair values were categorized within Level 3 of the fair value hierarchy and were determined using an income-based approach, which was based on the present value of the future estimated after-tax cash flows attributable to each intangible asset. The significant assumptions inherent in the development of the values, from the perspective of a market participant, include the amount and timing of projected future cash flows (including revenue, regulatory success and profitability), and the discount rate selected to measure the risks inherent in the future cash flows, which was between 18%-23%. These fair values are based on the most recent estimate of the fair value available and will be updated as we obtain more information.

(ii)The estimate of the useful life was based on an analysis of the expected use of the asset by us, any legal, regulatory or contractual provisions that may limit the useful life, the effects of obsolescence, competition and other relevant economic factors, and consideration of the expected cash flows used to measure the fair value of the intangible asset.

Summary of Pro-forma Financial Information

The following table summarizes the pro forma financial information (in thousands):


	For the Years Ended December 31,
		2021		2020
Net loss applicable to common stockholders and unitholders		$	(113,119)	$	(60,701)

Property and equipment, net (Details) - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020
Property, Plant and Equipment
Total Cost	$ 58,495	$ 11,254
Less accumulated depreciation and amortization	(6,381)	(2,345)
Property and equipment, net	52,114	8,909
Construction in progress
Property, Plant and Equipment
Total Cost	933	0
Lab Equipment
Property, Plant and Equipment
Property plant, equipment and finance lease assets, gross	27,776	8,578
Software
Property, Plant and Equipment
Total Cost	311	188
Furniture, Fixtures and Other
Property, Plant and Equipment
Total Cost	4,804	472
Leasehold Improvements
Property, Plant and Equipment
Total Cost	$ 24,671	$ 2,016

Summary of significant accounting policies - Collaborative Agreements (Details) - USD ($)	1 Months Ended		12 Months Ended
	Sep. 30, 2021	Dec. 31, 2019	Dec. 31, 2021	Dec. 31, 2020
Collaborative Arrangement and Arrangement Other than Collaborative
Deferred revenue			$ 1,400,000	$ 2,600,000
Contract assets			600,000	100,000
Revenue recognized from customer contract liability			1,500,000	200,000
Income tax interest and penalties payment			0	0
KBI BioPharma, Inc. \| Collaborative Arrangements
Collaborative Arrangement and Arrangement Other than Collaborative
Contract term (years)	3 years	4 years
Upfront payment received			800,000
Aggregate milestone payments			2,800,000
Cumulative proceed from collaborative agreements			2,300,000
Collaborative arrangement, collaboration agreement fee	$ 300,000
Deferred revenue			$ 1,200,000	$ 1,800,000

Related party transactions	12 Months Ended
Related party transactions	Dec. 31, 2021
Related Party Transactions [Abstract]
Related party transactions	Related party transactions The Company is party to a joint development agreement with AGC, Inc., the parent company of the employer of one of the Company’s former directors (resignation effective April 2021). No revenue was recognized under the agreement during 2021 through April 2021. Revenue recognized under the agreement for the year ended December 31, 2020 was $0.2 million. The Company has the opportunity to earn additional revenues under the agreement if pre-determined milestones are achieved. During the period ended December 31, 2021, the employer of one of the Company’s board members exercised a warrant to purchase 307,211 shares of the Company’s common stock. The Company’s total cash proceeds from the warrant’s exercise was $0.1 million.

Stock-based compensation - Allocated Share-based Compensation Expense (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020
Share-based Payment Arrangement, Expensed
Share-based compensation	$ 10,608	$ 420
Research and development
Share-based Payment Arrangement, Expensed
Share-based compensation	4,637	188
Selling, general and administrative
Share-based Payment Arrangement, Expensed
Share-based compensation	$ 5,971	$ 232

Acquisitions

12 Months Ended

Dec. 31, 2021

Business Combination and Asset Acquisition [Abstract]

Acquisitions

Acquisition of Denovium

In January 2021, the Company completed its acquisition of the common stock of Denovium, Inc. (“Denovium”), an artificial intelligence deep learning company focused on protein discovery and design. The Company is integrating Denovium’s technology into its Integrated Drug Creation Platform. The acquisition has been accounted for as a business combination.

Pursuant to the terms of the agreement, the Company acquired all outstanding equity of Denovium for estimated total consideration of $3.0 million, which consists of (in thousands):



Cash consideration	$	2,670
Equity consideration	368
Total purchase consideration	$	3,038

Cash consideration includes a $2.5 million upfront payment and a payment for working capital adjustments.

In addition to the $2.5 million paid upfront, $2.5 million was placed into escrow subject to the continued service and/or employment of Denovium’s co-founders over a one-year period. This amount is not included in the total consideration and is accounted for as compensation expense over the one-year service period, and is included in current restricted cash and accrued expenses on the consolidated balance sheet as of December 31, 2021.

The Company issued 1,010,296 shares of its common stock to the Denovium co-founders, of which 80% or 808,238 shares is subject to a Stock Restriction Agreement and vests monthly over a four-year term subject to a service condition. The fair value of these shares of $1.5 million will be recognized as compensation cost over the four-year service period. The remaining 20%, or 202,058 shares, vested immediately and is included in the total consideration.

The following table summarizes the allocation of the purchase consideration to the fair value of the assets acquired and liabilities assumed (in thousands):



Cash and cash equivalents	$	158
Accounts receivable	59
Other current assets	1
Intangible assets	2,507
Goodwill	1,055
TOTAL ASSETS	3,780
Accounts payable and accrued expenses	109
Deferred tax liability	633
TOTAL LIABILITIES	742
Fair value of net assets acquired and liabilities assumed	$	3,038

Goodwill arising from the acquisition of $1.1 million was attributable to the assembled workforce and expected synergies between the Integrated Drug Creation Platform and the Denovium Engine. The goodwill is not deductible for tax purposes. As of December 31, 2021, the Company had fully completed the analysis to assign fair values to all assets acquired and liabilities assumed.

The following table reflects the fair values of the identified intangible assets of Denovium and their respective weighted-average estimated amortization periods.



	Estimated Fair Value (in thousands)		Estimated Amortization Period (years)
Denovium Engine	$	2,507	5
	$	2,507

Acquisition of Totient

On June 4, 2021, the Company entered into a merger agreement with Totient, Inc. (“Totient”), under which, at the effective time, a wholly owned entity, or Merger Sub, merged with Totient, with Merger Sub surviving as a wholly owned subsidiary of the Company.

Pursuant to the merger agreement, at closing, Totient shareholders became eligible to receive an aggregate payment of $55.0 million in cash, of which $40.0 million in cash was paid at closing, subject to customary purchase price adjustments and escrow restrictions, and $15.0 million in cash shall be paid upon the achievement of expected milestones, and 2,212,208 shares of the Company’s common stock. The $40.0 million cash consideration includes $8.0 million of deferred cash payment, due in one year, which is held in escrow and included in current restricted cash and accrued expenses on the consolidated balance sheet as of December 31, 2021. All common stock issued is unrestricted, except for those shares granted to certain members of Totient’s management, of which 25% of the shares issued were vested upon the closing of the transaction and the remaining 75% will vest over 2.5 years, in six month installments subject to their continuing service relationships with the Company.

The following table summarizes the preliminary purchase price (in thousands):



Estimated cash payment to Totient stockholders	$	35,368	(i)
Estimated stock payment to Totient stockholders	13,891		(ii)
Estimated cash payment contingent on achieving specified milestone	12,000		(iii)
Total	$	61,259

The following table summarizes the allocation of the estimated consideration to the identifiable assets and liabilities acquired by us as of June 4, 2021 (in thousands).



Current assets:
Cash and cash equivalents	$	1,751
Prepaid expenses and other current assets	189
Total current assets	1,940
Operating lease right-of-use assets	266
Property and equipment, net	118
Goodwill	20,280		(i)
Intangible assets	54,600		(ii)
Other long-term assets	23
TOTAL ASSETS	77,227
Current liabilities:
Accounts payable	78
Accrued expenses	6,588
Operating lease obligations, current	122
Total current liabilities	6,788
Operating lease obligations - net of current portion	144
Deferred tax, net	9,012
Other long-term liabilities	24
TOTAL LIABILITIES	15,968
Fair value of net assets acquired and liabilities assumed	$	61,259

(ii)The estimated fair value of and useful lives of the intangible assets acquired is as follows:


	Estimated fair value (in thousands)(i)		Estimated useful lives (in years)(ii)
Monoclonal antibody library	$	46,300	20
Developed software platform and the related methods patents	8,300		15
Total	$	54,600

Until finalization, the Company’s analysis to assign fair values to all assets acquired and liabilities assumed is preliminary. The remaining items include the finalization of working capital adjustments, income taxes and contingent consideration liability, and the resulting impact to goodwill. The preliminary purchase price allocation will be subject to further refinement as the Company continues to refine its estimates and assumptions based on information available at the acquisition date. These refinements may result in material changes to the estimated fair value of assets acquired and liabilities assumed. The purchase price allocation adjustments can be made throughout the end of the Company’s measurement period, which is not to exceed one year from the acquisition date. The effect of measurement period adjustments to the estimated amounts

will be reflected on a prospective basis. During the year ended December 31, 2021, the Company recorded adjustments to goodwill of $1.6 million primarily related to deferred taxes.

Acquisition costs of $0.9 million were included in the consolidated statement of operations and comprehensive loss as selling, general and administrative. The Company’s results of operations for the year ended December 31, 2021 include the operating results of Totient since the date of acquisition, within the consolidated statement of operations and comprehensive loss.

The unaudited financial information in the table below summarizes the combined results of operations of the Company and Totient on a pro forma basis, as though the companies had been combined as of January 1, 2020. These pro forma results were based on estimates and assumptions, which we believe are reasonable. The pro forma financial information is presented for informational purposes only and is not indicative of the results of operations that would have been achieved if the acquisition had taken place at the beginning of our fiscal year 2020. The pro forma financial information includes adjustments to share-based compensation expense, amortization for acquired intangible assets, interest expense, and transaction costs, and related tax effects.

The pro forma financial information for the years ended December 31, 2021 and 2020 combines our results, which include the results of Totient subsequent to June 4, 2021, and the historical results for Totient for the periods prior to acquisition. The pro forma results for the year ended December 31, 2020 also include material nonrecurring adjustments for $0.9 million of acquisition related costs incurred and $1.6 million of costs related to the acceleration of stock appreciation right (“SAR”) and Employee Stock Ownership Plan awards due to preexisting change in control provisions.

The following table summarizes the pro forma financial information (in thousands):


	For the Years Ended December 31,
		2021		2020
Net loss applicable to common stockholders and unitholders		$	(113,119)	$	(60,701)

Goodwill and Intangibles, net (Tables)

12 Months Ended

Dec. 31, 2021

Goodwill and Intangible Assets Disclosure [Abstract]

Schedule of Goodwill

The roll forward of goodwill was as follows (in thousands):



Balance, December 31, 2020	$	—
Goodwill acquired related to acquisition of Denovium	1,055
Goodwill acquired related to acquisition of Totient	20,280
Balance, December 31, 2021	$	21,335

Schedule of Finite-Lived Intangible Assets

Intangible assets consisted of the following:



	December 31, 2021
	Gross Assets		Accumulated Amortization		Net
Denovium Engine	2,507		(473)		2,034
Monoclonal antibody library	46,300		(1,325)		44,975
Developed software platform and the related methods patents	8,300		(317)		7,983
Intangible assets, net	$	57,107	$	(2,115)	$	54,992

Schedule of Finite-Lived Intangible Assets, Future Amortization Expense

At December 31, 2021, amortization expense on intangible assets is estimated to be as follows for each of the next five years:



Years Ending December 31:
2022	$	3,370
2023	3,370
2024	3,370
2025	3,370
2026	2,897
Thereafter	38,615
	$	54,992

Leases - Components of Lease Expense (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020
Leases [Abstract]
Operating lease cost	$ 1,780	$ 526
Variable lease cost	425	166
Short-term lease cost	155	18
Lease, cost	$ 2,360	$ 710

Net loss per share attributable to common stockholders and unitholders (Tables)

12 Months Ended

Dec. 31, 2021

Earnings Per Share [Abstract]

Schedule of Company’s Basic and Diluted Net Loss Per Share Attributable to Common Unitholders and Stockholders

The following table sets forth the computation of the Company’s basic and diluted net loss per share attributable to common unitholders and stockholders (in thousands, except share and per share amounts):




	2021		2020
Numerator:
Net loss	$	(100,960)	$	(14,353)
Adjustment of redeemable convertible preferred stock and units	—		(34,336)
Cumulative undeclared preferred stock dividends	(2,284)		(780)
Net loss available to common stockholder and unitholders	$	(103,244)	$	(49,469)

Denominator:
Weighted-average common shares and units outstanding	49,685,194		15,494,908

Net loss per share, basic and diluted	$	(2.08)	$	(3.19)

Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share

Potentially dilutive securities not included in the calculation of diluted net loss per share because to do so would be anti-dilutive are as follows (in common stock equivalent shares):




	2021	2020
Redeemable convertible preferred stock and units outstanding	25,489,573	45,424,373
Redeemable convertible preferred stock and unit warrants	189,377	307,211

Stock options	6,379,236	1,645,237
Unvested restricted stock	2,616,641	1,111,642

Goodwill and Intangibles, net - Schedule of Finite-Lived Intangible Assets, Future Amortization Expense (Details) $ in Thousands	Dec. 31, 2021 USD ($)
Years Ending December 31:
2022	$ 3,370
2023	3,370
2024	3,370
2025	3,370
2026	2,897
Thereafter	38,615
Net	$ 54,992

Commitment and Contingencies	12 Months Ended
Commitment and Contingencies	Dec. 31, 2021
Commitments and Contingencies Disclosure [Abstract]
Commitments and contingencies	Commitments and contingenciesAs of December 31, 2021, future lease payments are secured by irrevocable standby letters of credit totaling $1.8 million. The irrevocable standby letters of credit are expected to be pledged for the full lease terms which extend through 2024 and 2028 for each of the Company’s facility leases.The Company is not currently party to any material claims or legal proceedings. At each reporting date, the Company evaluates whether or not a potential loss or a potential range of loss is both probable and reasonably estimable.

Fair Value Measurements

12 Months Ended

Dec. 31, 2021

Fair Value Disclosures [Abstract]

Fair Value Measurements

US GAAP defines fair value, establishes a consistent framework for measuring fair value and expands disclosure for each major asset and liability category measured at fair value on either a recurring or nonrecurring basis. Fair value is defined as an exit price, representing the amount that would be received to sell an asset or paid to transfer a liability in an orderly transaction between market participants. As such, fair value is a market-based measurement that should be determined based on assumptions that market participants would use in pricing an asset or liability. As a basis for considering such assumptions, the accounting guidance establishes a three-tier fair value hierarchy, which prioritizes the inputs used in measuring fair value as follows:

Level 1: Observable inputs such as quoted prices in active markets.

Level 2: Inputs, other than the quoted prices in active markets, that are observable either directly or indirectly.

Level 3: Unobservable inputs in which there is little or no market data, which require the reporting entity to develop its own assumptions.

When quoted market prices are available in active markets, the fair value of assets and liabilities is estimated within Level 1 of the valuation hierarchy.

If quoted prices are not available, then fair values are estimated by using pricing models, quoted prices of assets and liabilities with similar characteristics, or discounted cash flows, within Level 2 of the valuation

hierarchy. In cases where Level 1 or Level 2 inputs are not available, the fair values are estimated by using inputs within Level 3 of the hierarchy.

As part of the Class A-1 funding in 2016, a warrant for the purchase of 93,007 Class A-1 Preferred Units at an exercise price of $1 per unit and exercisable at any time before April 2026 was granted to an investor. This warrant was exchanged for a warrant to purchase Series A-1 preferred stock at equivalent terms in October 2020 (Note 9: Redeemable convertible preferred stock). Because the underlying shares are redeemable for conditions outside of the Company’s control, the warrant was classified within other long-term liabilities on the consolidated balance sheets and recognized at fair value at each reporting period with the change in fair value recorded in other expense on the consolidated statement of operations and comprehensive loss through the date of the IPO. The value for the warrant was based on significant inputs not observable in the market, which represents a Level 3 measurement within the fair value hierarchy.

During 2018, the Company entered into an agreement whereby the Company is required to pay a fee of 3.5% of the aggregate amount of term loans funded by Bank under the LSA within three business days of a sale or other disposition of substantially all of the Company’s assets, a merger or consolidation, a change in control or an initial public offering (Note 6: Long-term debt and other borrowings). This agreement has been accounted for as a freestanding derivative under ASC 815, Derivatives and is remeasured to its fair value at the end of each reporting period. The value for the fee (“Fee in lieu of warrant”) is based on significant inputs not observable in the market, which represents a Level 3 measurement within the fair value hierarchy. Except for short-term investments, the 2021 Notes and the warrant, none of the Company’s assets or liabilities are recorded at fair value on a recurring basis.

The following table summarizes the Company’s assets and liabilities measured at fair value on a recurring basis as of December 31, 2021 and December 31, 2020 (in thousands):



	December 31, 2021
	Level 1		Level 2		Level 3		Total
Assets:
Equity securities without RDFV	$	—	$	—	$	1,200	$	1,200
Total assets	$	—	$	—	$	1,200	$	1,200
Liabilities:



Contingent consideration	$	—	$	—	$	12,000	$	12,000
Total liabilities	$	—	$	—	$	12,000	$	12,000



	December 31, 2020
	Level 1		Level 2		Level 3		Total



Liabilities:
Fee in-lieu of warrant	$	—	$	—	$	22	$	22

Preferred stock warrant liability	—		—		698		698

Total liabilities	$	—	$	—	$	720	$	720

The following table provides reconciliation for all liabilities measured at fair value using significant unobservable inputs (Level 3) for the year ended December 31, 2021 (in thousands):



	Fee in-lieu of warrant		Convertible promissory notes		Preferred stock warrant liability		Contingent consideration		Total liabilities
Balance at December 31, 2020	$	22	$	—	$	698	$	—	$	720
Fair value at issuance	—		125,000		—		12,000		137,000
Change in fair value during 2021	174		30,722		4,124		—		35,020
Conversion or payment at IPO	(196)		(155,722)		(4,822)		—		(160,740)
Balance at December 31, 2021	$	—	$	—	$	—	$	12,000	$	12,000

Based on the probability of a liquidity event, the Company primarily utilized the expected IPO price to estimate the fair value of the preferred stock warrant liability through the IPO date. The warrant was converted into a warrant to purchase 307,211 shares of the Company’s common stock upon the closing of the IPO and was exercised to purchase common stock during the period ended December 31, 2021 following the IPO.

The fee-in-lieu of warrant liability is measured based on management’s estimate of the probability of a liquidity event, the estimated timing thereof, and a discount rate. The fee-in-lieu of warrant was paid during the period ended December 31, 2021 following the IPO.

The Company measured the fair value of the 2021 Notes at issuance using the transaction price. For the period from the issuance date through the IPO date, the Company increased the estimated fair value based on the increased probability of an IPO. The 2021 Notes converted to common stock during the period ended December 31, 2021 immediately prior to the IPO.

The contingent consideration liability is related to the Totient acquisition and is included in Other long-term liabilities on the consolidated balance sheet as of December 31, 2021. Refer to Note 3: Acquisitions for further information.

The fair value of equity securities without readily determinable fair market values (“RDFV”) is determined based on cost, less any impairment, plus or minus changes in fair value resulting from observable price changes in orderly transactions for an identical or similar investment of the same issuer. These securities are classified as Level 3 in the fair value hierarchy outlined above.

There are significant judgments, assumptions and estimates inherent in the determination of the fair value of each of the instruments described above. These include determination of a valuation method and selection of the possible outcomes available to the Company, including the determination of timing and expected future investment returns for such scenarios. Prior to the IPO, the Company considered the equity value of an initial public offering using market transactions and determined the expected value of a stay private scenario using the income approach, which was based on assumptions regarding the Company’s future operating performance. The related judgments, assumptions and estimates are highly interrelated and changes in any one assumption could necessitate changes in another. In particular, any changes in the probability of a particular outcome would require a related change to the probability of another outcome. In addition, the fair value of the 2021 Notes is derived using assumptions that are consistent with the assumptions used to value the Company’s common stock, the fee in-lieu of warrant and the warrant. In the future, depending on the valuation approaches used and the expected timing and weighting of each, the inputs described above, or other inputs, may have a greater or lesser impact on the Company’s estimates of fair value.

- Definition

The entire disclosure for the fair value of financial instruments (as defined), including financial assets and financial liabilities (collectively, as defined), and the measurements of those instruments as well as disclosures related to the fair value of non-financial assets and liabilities. Such disclosures about the financial instruments, assets, and liabilities would include: (1) the fair value of the required items together with their carrying amounts (as appropriate); (2) for items for which it is not practicable to estimate fair value, disclosure would include: (a) information pertinent to estimating fair value (including, carrying amount, effective interest rate, and maturity, and (b) the reasons why it is not practicable to estimate fair value; (3) significant concentrations of credit risk including: (a) information about the activity, region, or economic characteristics identifying a concentration, (b) the maximum amount of loss the entity is exposed to based on the gross fair value of the related item, (c) policy for requiring collateral or other security and information as to accessing such collateral or security, and (d) the nature and brief description of such collateral or security; (4) quantitative information about market risks and how such risks are managed; (5) for items measured on both a recurring and nonrecurring basis information regarding the inputs used to develop the fair value measurement; and (6) for items presented in the financial statement for which fair value measurement is elected: (a) information necessary to understand the reasons for the election, (b) discussion of the effect of fair value changes on earnings, (c) a description of [similar groups] items for which the election is made and the relation thereof to the balance sheet, the aggregate carrying value of items included in the balance sheet that are not eligible for the election; (7) all other required (as defined) and desired information.

+ References + Details

Redeemable convertible preferred stock (Tables)

12 Months Ended

Dec. 31, 2021

Temporary Equity Disclosure [Abstract]

Schedule of Stock by Class

The following table summarizes the authorized, issued, and outstanding redeemable convertible preferred stock of the Company as of December 31, 2020 (in thousands, except share and per share data):


	December 31, 2020
	Shares Authorized	Shares Issued and Outstanding	Issuance Price per Share		Net Proceeds		Liquidation Preference
Convertible Preferred Stock:
Junior	1,573,547	1,573,547	$	1.00	$	1,462	$	1,989
Series A-1	2,793,007	2,700,000	1.00		2,700		3,453
Series A-2	1,500,000	1,500,000	1.00		1,500		1,885
Series B	1,372,549	1,372,549	1.53		2,065		2,526
Series C	1,760,252	1,760,252	6.95		11,979		14,110
Series D	1,532,176	1,532,176	9.79		14,951		15,852
Series E	3,313,519	3,313,519	19.62		64,709		163,280
Total convertible preferred stock	13,845,050	13,752,043			$	99,366	$	203,095

Long-term debt and other borrowings

12 Months Ended

Dec. 31, 2021

Debt Disclosure [Abstract]

Long-term debt and other borrowings

Long-term debt and other borrowingsIn June 2018, the Company signed a Loan and Security Agreement (“LSA”) with Bridge Bank (“Bank”), a division of Western Alliance Bank. The purpose of the LSA was to provide long-term financing to the

Company through term loans available for borrowing in three tranches up to a maximum of $3.0 million through December 2019 upon the attainment of certain milestones as delineated in the LSA. The first tranche of $0.3 million was borrowed in 2018. The Company was obligated to make interest-only payments until the amortization date of June 28, 2019 and after that date to make principal and interest payments. Interest on outstanding borrowings under the LSA is charged at a rate of 6% per annum. This loan was scheduled to originally matured in May 2022, at which time all outstanding principal and accrued and unpaid interest is due and payable. This loan is secured by substantially all tangible assets of the Company; intellectual property is excluded from the secured collateral but is subject to a negative pledge in favor of the Bank.

In March 2019, the Company entered into a first amendment to the LSA that increased total borrowings to $3.0 million and added a financial liquidity covenant. The amendment was accounted for as a debt modification and no gain or loss was recognized in the Company’s financial statements.

In May 2020, the Company entered into a second amendment to the LSA that increased total borrowings to $5.0 million. The amortization date was extended to May 1, 2021 except, if a certain revenue and new contract bookings milestone is achieved, the amortization date is extended to November 1, 2021. The maturity date of the loan was extended to May 11, 2024. The amendment was accounted for as a debt modification and no gain or loss was recognized in the Company’s financial statements.

In August 2020, the Company entered into a third amendment to the LSA that waived an event of default due to failure to meet a financial covenant. The amendment also expanded the definition of permitted indebtedness to include Payroll Protection Plan (“PPP”) loans, and modified financial and restrictive covenants.

In February 2021, the Company entered into a fourth amendment to the LSA. This amendment gave effect to the Company’s conversion to a corporation and its purchase of Denovium, including permitting certain cash and equity consideration linked to continued employment and service requirements, and adding Denovium as co-borrower to the LSA.

In June 2021, the Company entered into a fifth amendment to the LSA. This amendment modified the term loan’s maturity date to June 16, 2023.

The Company may prepay all, but not less than all, of the term loans at any time upon 10 days written notice, with a prepayment premium beginning at 1.0% initially and declining to 0% after May 11, 2022. The Company is also required to pay a final payment equal to 3% of the principal amount funded, which is payable upon the earliest to occur of (i) the maturity date, (ii) acceleration and (iii) the prepayment of the loan. As part of the second amendment, the Company paid a one-time amendment fee and a pro-rated final payment in connection with the amendment. The final payment represents an additional principal payment and is accounted for as a debt discount that will be accreted through the maturity date of the loan based on the effective interest method.

In connection with entering into the LSA in June 2018, the Company entered into an agreement whereby the Company is required to pay a fee of 3.5% of the aggregate amount of term loans funded by Bank under the LSA within three business days of a sale or other disposition of substantially all of the Company’s assets, a merger or consolidation, a change in control or an initial public offering. Concurrent with the second amendment, the Company and the Bank entered into an amended agreement which extended the term of the fee to May 11, 2030. This fee became payable upon completion of the Company’s IPO on July 26, 2021 and was paid during the year ended December 31, 2021.

Under the LSA (as amended), the Company is subject to a financial covenant. The covenant, as amended, requires that the Company maintain at all times either (a) unrestricted cash and cash equivalents in an amount equal to or greater than the Company’s monthly cash burn or (b) trailing 6-month revenue of at least 80% of the Company’s revenue projections (over the same 6-month period) determined using the lender’s measurement method. As of December 31, 2021, the Company was in compliance with this financial covenant.

As of December 31, 2021, the outstanding principal balance under the LSA was $3.4 million.

Future maturities of the amounts outstanding under the LSA as of December 31, 2021 are as follows (in thousands):



Years ending December 31:
2022	$	2,400
2023	1,150
2024	—
2025	—
2026	—
Total principal, including final fee	3,550
Less: amount representing debt discounts and issuance costs	(26)
Total long-term debt	$	3,524

The carrying amount of the long-term debt approximates fair value.

In May 2020, the Company received a PPP loan pursuant to the Coronavirus Aid, Relief, and Economic Security Act (“CARES Act”) in the amount of $0.6 million. The loan had a two-year term and bore a fixed interest rate of 1%. Under the terms of the CARES Act, the loan was eligible to be forgiven, in part or whole, if the proceeds were used to retain and pay employees and for other qualifying expenditures. In February 2021, the Company received notification from the Small Business Administration that they approved the forgiveness of the full $0.6 million PPP loan and a gain on extinguishment in this amount was recorded as other income in the consolidated statement of operations and comprehensive loss.

In March 2021, the Company entered into a Note Purchase Agreement to issue and sell $125.0 million convertible promissory notes (the “2021 Notes”) to certain investors. The 2021 Notes accrued interest at 6% per annum. Due to certain embedded features within the 2021 Notes, the Company elected to account for these notes, including all of their embedded features, under the fair value option. The Company has elected to recognize interest expense based on the 6% per annum coupon rate of the Notes, which was included in other long-term liabilities on the consolidated balance sheet through the date of the IPO. Based on the terms of the agreement, the 2021 Notes converted at an 18% discount from the offering price to the public in the IPO. Prior to the conversion, the Company recorded a final fair value adjustment of the 2021 Notes using the Company's common stock price at the IPO. Immediately prior to the completion of the IPO, all outstanding principal under the 2021 Notes and the related accrued interest expense were converted into an aggregate of 9,732,593 shares of our common stock based on an initial public offering price of $16.00 per share.

- Definition

The entire disclosure for information about short-term and long-term debt arrangements, which includes amounts of borrowings under each line of credit, note payable, commercial paper issue, bonds indenture, debenture issue, own-share lending arrangements and any other contractual agreement to repay funds, and about the underlying arrangements, rationale for a classification as long-term, including repayment terms, interest rates, collateral provided, restrictions on use of assets and activities, whether or not in compliance with debt covenants, and other matters important to users of the financial statements, such as the effects of refinancing and noncompliance with debt covenants.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 470
-URI http://asc.fasb.org/topic&trid=2208564

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 470
-SubTopic 20
-Section 50
-Paragraph 1B
-Subparagraph (h)
-URI http://asc.fasb.org/extlink&oid=123466505&loc=SL123495323-112611

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
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-Name Accounting Standards Codification
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-SubTopic 20
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Reference 4: http://www.xbrl.org/2003/role/disclosureRef
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Reference 5: http://www.xbrl.org/2003/role/disclosureRef
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Reference 6: http://www.xbrl.org/2003/role/disclosureRef
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-Name Accounting Standards Codification
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-Section S99
-Paragraph 1
-Subparagraph (SX 210.4-08(c))
-URI http://asc.fasb.org/extlink&oid=120395691&loc=d3e23780-122690

Reference 7: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 470
-SubTopic 20
-Section 50
-Paragraph 1B
-Subparagraph (g)
-URI http://asc.fasb.org/extlink&oid=123466505&loc=SL123495323-112611

Reference 8: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
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Reference 9: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
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-Paragraph 1C
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-URI http://asc.fasb.org/extlink&oid=123466505&loc=SL123495334-112611

Reference 10: http://www.xbrl.org/2003/role/disclosureRef
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-Name Accounting Standards Codification
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-URI http://asc.fasb.org/extlink&oid=123466505&loc=SL123495348-112611

Reference 11: http://www.xbrl.org/2003/role/disclosureRef
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-Name Accounting Standards Codification
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-URI http://asc.fasb.org/extlink&oid=123466505&loc=SL123495323-112611

Reference 12: http://www.xbrl.org/2003/role/disclosureRef
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-URI http://asc.fasb.org/extlink&oid=123466505&loc=SL123495371-112611

Reference 13: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
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-URI http://asc.fasb.org/extlink&oid=123466505&loc=SL123495323-112611

+ Details

Leases

12 Months Ended

Dec. 31, 2021

Leases [Abstract]

Leases

In December 2020, the Company entered into a lease agreement for a new 61,607 square foot facility in Vancouver, Washington. The lease term commenced in December 2020 and initially was set to end in April 2026, with the Company’s option to renew through April 2031. The lease agreement provides for annual base rent of approximately $1.2 million in the first year of the lease term which increases on an annual basis to approximately $1.5 million in the final year of the initial lease term. As part of the lease agreement, the lessor provided tenant incentives in the amount of $2.5 million.

In March 2021, the Company entered into an amendment to its lease agreement with respect to its new facility currently under construction. The amendment made certain changes to the original lease, including (i) the addition of 16,367 square feet of office and laboratory space at the same site (“Expansion Premises”) and (ii) an extension of the expiration date of the original lease by 24 months following the rent commencement date of April 1, 2021. The amendment provides for annual base rent for the Expansion Premises of approximately $0.3 million in the first year of the lease term, which increases on an annual basis to approximately $0.4 million in the final year of the lease term. The amendment also provides for additional tenant incentives in the amount of $0.7 million. Additionally, with the execution of this amendment, the Company obtained a one-time option to terminate the lease for the original premises and Expansion Premises after five years. All other terms of the lease amendment for the Expansion Premises are consistent with the

existing new facility lease agreement. Under the amendment, the Company retains its original option to renew the lease for an additional five-year term, at then-current market rates.

In conjunction with the new facility lease and lease amendment, the Company entered into an agreement with a construction company for purposes of building out the facility and customizations for a total estimated cost of approximately $24.5 million.

The Company moved into its new facility in May 2021 and has completed its move out of its prior office and laboratory facility, for which the Company’s lease continues through August 2024. During the fourth quarter of 2021, the Company determined it would no longer utilize the prior office and facility and is currently evaluating different options with the lessor. As a result, during the year ended December 31, 2021, the Company recognized $0.6 million in impairment expense of certain operating lease right-of-use assets and $0.3 million in impairment of leasehold improvements.

For each of the Company’s facility lease agreements, the Company is responsible for taxes, insurance and maintenance costs.

The Company leases certain laboratory equipment under finance leases. Property and equipment includes approximately $8.8 million and $4.3 million of assets under finance leases as of December 31, 2021 and 2020, respectively. Accumulated depreciation related to assets under finance leases was approximately $1.8 million and $0.9 million as of December 31, 2021 and 2020, respectively.

The components of lease expense were as follows (in thousands):



	For the Years Ended December 31,
	2021		2020
Operating lease cost	1,780		526
Variable lease cost	425		166
Short-term lease cost	155		18
	$	2,360	$	710

Future undiscounted lease payments for the Company’s lease liabilities as of December 31, 2021 are as follows (in thousands):


	Operating leases		Finance leases
2022	$	2,294	$	3,127
2023	2,285		2,477
2024	2,135		968
2025	1,873		86
2026	1,929		—
Thereafter	2,821		—
Total future lease payments	13,337		6,658
Less: Imputed interest	(2,832)		(642)
Less: Lease incentive	(34)		—
Present value of lease liabilities	$	10,471	$	6,016

Additional information related to the Company’s leases as of December 31, 2021 and 2020 is as follows:


	December 31, 2021		December 31, 2020
Weighted average remaining lease term (in years)
Operating leases	6		4.9
Finance leases	2.2		3.0

Weighted average discount rate
Operating leases	8	%	8	%
Finance leases	7	%	7	%

Leases

existing new facility lease agreement. Under the amendment, the Company retains its original option to renew the lease for an additional five-year term, at then-current market rates.

For each of the Company’s facility lease agreements, the Company is responsible for taxes, insurance and maintenance costs.

The components of lease expense were as follows (in thousands):



	For the Years Ended December 31,
	2021		2020
Operating lease cost	1,780		526
Variable lease cost	425		166
Short-term lease cost	155		18
	$	2,360	$	710

Future undiscounted lease payments for the Company’s lease liabilities as of December 31, 2021 are as follows (in thousands):


	Operating leases		Finance leases
2022	$	2,294	$	3,127
2023	2,285		2,477
2024	2,135		968
2025	1,873		86
2026	1,929		—
Thereafter	2,821		—
Total future lease payments	13,337		6,658
Less: Imputed interest	(2,832)		(642)
Less: Lease incentive	(34)		—
Present value of lease liabilities	$	10,471	$	6,016

Additional information related to the Company’s leases as of December 31, 2021 and 2020 is as follows:


	December 31, 2021		December 31, 2020
Weighted average remaining lease term (in years)
Operating leases	6		4.9
Finance leases	2.2		3.0

Weighted average discount rate
Operating leases	8	%	8	%
Finance leases	7	%	7	%

Income Taxes - Benefit from (Provision for) Income Taxes (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020
Current
Federal	$ 0	$ 0
State	2	2
Total current	2	2
Deferred expense/(benefit)
Federal	(7,254)	0
State	(1,647)	0
Total deferred	(8,901)	0
Income tax benefit	$ (8,899)	$ 2

CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020
Current assets:
Cash and cash equivalents	$ 252,569	$ 69,867
Restricted cash	10,513	0
Receivables under development arrangements	1,425	1,594
Prepaid expenses and other current assets	8,572	1,773
Total current assets	273,079	73,234
Operating lease right-of-use assets	6,538	4,476
Property and equipment, net	52,114	8,909
Intangibles, net	54,992	0
Goodwill	21,335	0
Restricted cash, long-term	16,844	1,841
Other long-term assets	1,293	109
TOTAL ASSETS	426,195	88,569
Current liabilities:
Accounts payable	8,385	2,116
Accrued expenses	17,434	1,569
Loans payable	0	632
Long-term debt, current	2,400	903
Operating lease obligations, current	1,502	770
Financing lease obligations, current	2,785	1,475
Deferred revenue, current	1,353	2,630
Total current liabilities	33,859	10,095
Long-term debt - net of current portion	1,124	4,141
Operating lease obligations - net of current portion	8,969	3,813
Finance lease obligations - net of current portion	3,231	2,766
Deferred tax, net	743	0
Other long-term liabilities	12,162	749
TOTAL LIABILITIES	60,088	21,564
Commitments (See Note 8)
Redeemable convertible preferred stock, $0.0001 par value; 0 and 13,845,050 shares authorized as of December 31, 2021 and December 31, 2020, respectively; 0 and 13,752,043 issued and outstanding as of December 31, 2021 and December 31, 2020 respectively; liquidation preference of $203,095 as of December 31, 2020;	0	156,433
STOCKHOLDERS' DEFICIT
Preferred stock, $0.0001 par value; 10,000,000 and 0 shares authorized as of December 31, 2021 and December 31, 2020, respectively; 0 shares issued and outstanding as of December 31, 2021 and December 31, 2020, respectively	0	0
Common stock, $0.0001 par value; 500,000,000 and 72,668,200 shares authorized as of December 31, 2021 and December 31, 2020, respectively; 92,648,036 and 17,887,631 shares issued and outstanding as of December 31, 2021 and December 31, 2020, respectively	9	2
Additional paid-in capital	557,136	635
Accumulated deficit	(191,025)	(90,065)
Accumulated other comprehensive loss	(13)	0
TOTAL OTHER STOCKHOLDERS' DEFICIT	366,107	(89,428)
TOTAL LIABILITIES, REDEEMABLE CONVERTIBLE PREFERRED STOCK AND OTHER STOCKHOLDERS' DEFICIT	$ 426,195	$ 88,569

Income Taxes - Reconciliation of Income Tax Rate to Effective Tax Rate (Details)	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020
Effective Income Tax Rate Reconciliation, Percent [Abstract]
Expected federal income tax	21.00%	21.00%
State income taxes after credits	4.80%	4.20%
Tax-effect of change in entity status	0.30%	(3.70%)
Change in valuation allowance	(9.10%)	(3.30%)
Research and development credits	0.60%	0.10%
Stock-based compensation	(0.90%)	(0.40%)
Revaluation of warrant liability	(1.00%)	(0.20%)
Change in fair value of convertible promissory notes	(6.60%)	0.00%
Loss allocable to pre-incorporation period	0.00%	(17.70%)
Other	(1.00%)	0.00%
Effective tax rate	8.10%	0.00%

Leases - Narrative (Details)	1 Months Ended	12 Months Ended
Leases - Narrative (Details)	Mar. 31, 2021 USD ($) ft²	Dec. 31, 2021 USD ($)	Dec. 31, 2020 USD ($) ft²
Lessee, Lease
Operating lease, impairment loss		$ 600,000
Impairment of long lived assets			$ 0
Finance lease, net		8,800,000	4,300,000
Finance lease, accumulated depreciation		1,800,000	$ 900,000
Leasehold Improvements
Lessee, Lease
Impairment of long lived assets		$ 300,000
Facility in Vancouver Washington
Lessee, Lease
Area of real estate (sqft) \| ft²			61,607
Tenant incentives			$ 2,500,000
Extension term (months)	24 months
Renewal term (years)	5 years
Estimated construction cost			24,500,000
Facility in Vancouver Washington \| Minimum
Lessee, Lease
Annual base rent			1,200,000
Facility in Vancouver Washington \| Maximum
Lessee, Lease
Annual base rent			$ 1,500,000
Facility in Vancouver Washington Expansion Premises
Lessee, Lease
Area of real estate (sqft) \| ft²	16,367
Tenant incentives	$ 700,000
Lessee operating lease option to extend term	5 years
Facility in Vancouver Washington Expansion Premises \| Minimum
Lessee, Lease
Annual base rent	$ 300,000
Facility in Vancouver Washington Expansion Premises \| Maximum
Lessee, Lease
Annual base rent	$ 400,000

Leases - Future Undiscounted Lease Payments (Details) $ in Thousands	Dec. 31, 2021 USD ($)
Operating leases
2022	$ 2,294
2023	2,285
2024	2,135
2025	1,873
2026	1,929
Thereafter	2,821
Total future lease payments	13,337
Less: Imputed interest	(2,832)
Less: Lease incentive	(34)
Present value of lease liabilities	10,471
Finance leases
2022	3,127
2023	2,477
2024	968
2025	86
2026	0
Thereafter	0
Total future lease payments	6,658
Less: Imputed interest	(642)
Less: Lease incentive	0
Present value of lease liabilities	$ 6,016

Stock-based compensation - Restricted Stock Narratives (Details) - USD ($) $ in Millions	1 Months Ended	12 Months Ended
	Oct. 31, 2020	Dec. 31, 2021
2015 Plan
Share-based Compensation Arrangement by Share-based Payment Award
Partner capital units converted (units)	3,329,707
Restricted stock \| 2020 Plan
Share-based Compensation Arrangement by Share-based Payment Award
Conversion of redeemable convertible preferred stock (in shares)	2,671,907
Share based compensation expense not yet recognized other than options		$ 11.5
Share based compensation expense not yet recognized, recognition period (years)		2 years 7 months 6 days

Stock-based compensation - Stock Option Rollforward (Details) - USD ($) $ / shares in Units, $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020
Number of Options
Beginning balance, shares	1,706,339
Granted, shares	7,386,667
Exercised, shares	(153,416)
Canceled/Forfeited, in shares	(1,182,189)
Ending balance, shares	7,757,401	1,706,339
Exercisable, shares	1,675,979
Vested and expected to vest, shares	7,757,401
Weighted Average Exercise Price per Share
Beginning balance, usd per share	$ 1.10
Granted, usd per share	4.01
Exercised, usd per share	1.10
Canceled/Forfeited, usd per share	2.14
Ending balance, usd per share	3.72	$ 1.10
Exercisable, weighted average price, usd per share	$ 1.13
Weighted Average Remaining Contractual Term (in years)	9 years 2 months 12 days	9 years 9 months 18 days
Exercisable, weighted average remaining contractual term (in years)	9 years
Vested and expected to vest, contractual term (in years)	9 years 2 months 12 days
Intrinsic value, shares outstanding	$ 40,939	$ 780
Exercisable, aggregate intrinsic value	11,851
Vested and expected to vest, aggregate intrinsic value	$ 40,939

CONSOLIDATED BALANCE SHEETS (Parenthetical) - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020
Common stock, par value (usd per share)	$ 0.0001	$ 0.0001
Common stock, shares authorized (in shares)	500,000,000	72,668,200
Common stock, shares, issued (in shares)	92,648,036	17,887,631
Common stock, shares, outstanding (in shares)	92,648,036	17,887,631
Redeemable Convertible Preferred Stock [Member]
Preferred stock, par value (usd per share)	$ 0.0001	$ 0.0001
Preferred stock, shares authorized (in shares)	0	13,845,050
Preferred stock, shares issued (in shares)	0	13,752,043
Preferred stock, shares outstanding (in shares)	0	13,752,043
Liquidation Preference		$ 203,095
Preferred stock
Preferred stock, par value (usd per share)	$ 0.0001	$ 0.0001
Preferred stock, shares authorized (in shares)	10,000,000	0
Preferred stock, shares issued (in shares)	0	0
Preferred stock, shares outstanding (in shares)	0	0

Net loss per share attributable to common stockholders and unitholders - Company’s Basic and Diluted Net Loss Per Share (Details) - USD ($) $ / shares in Units, $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020
Numerator:
Net Income (Loss) Attributable to Parent	$ (100,960)	$ (14,353)
Adjustment of redeemable preferred units and stock	0	(34,336)
Undistributed earnings (loss) allocated to participating securities, basic	(2,284)	(780)
Net loss applicable to common stockholders and unitholders, diluted	(103,244)	(49,469)
Net loss applicable to common stockholders and unitholders, basic	$ (103,244)	$ (49,469)
Denominator:
Weighted-average common shares and units outstanding, basic (in shares)	49,685,194	15,494,908
Weighted-average common shares and units outstanding, diluted (in shares)	49,685,194	15,494,908
Net loss per share, basic (usd per share)	$ (2.08)	$ (3.19)
Net loss per share, basic (usd per share)	$ (2.08)	$ (3.19)

CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020
Revenues
Technology development revenue	$ 4,009	$ 4,117
Collaboration revenue	773	663
Total revenues	4,782	4,780
Operating expenses
Research and development	44,586	11,448
Selling, general and administrative	28,780	5,502
Depreciation and amortization	6,654	1,131
Total operating expenses	80,020	18,081
Operating loss	(75,238)	(13,301)
Other expense
Interest expense	(3,432)	(634)
Other expense, net	(31,189)	(418)
Total other expense, net	(34,621)	(1,052)
Loss before income taxes	(109,859)	(14,353)
Income tax benefit	8,899	0
Net loss	(100,960)	(14,353)
Adjustment of redeemable preferred units and stock	0	(34,336)
Cumulative undeclared preferred stock dividends	(2,284)	(780)
Net loss applicable to common stockholders and unitholders, basic	(103,244)	(49,469)
Net loss applicable to common stockholders and unitholders, diluted	$ (103,244)	$ (49,469)
Net loss per share attributable to common stockholders and unitholders, basic (usd per share)	$ (2.08)	$ (3.19)
Net loss per share attributable to common stockholders and unitholders, diluted (usd per share)	$ (2.08)	$ (3.19)
Weighted-average common shares and units outstanding, basic (in shares)	49,685,194	15,494,908
Weighted-average common shares and units outstanding, diluted (in shares)	49,685,194	15,494,908
Comprehensive loss:
Net Income (Loss) Attributable to Parent	$ (100,960)	$ (14,353)
Foreign currency translation adjustments	(13)	0
Comprehensive loss	$ (100,973)	$ (14,353)

Employee benefit plan	12 Months Ended
Employee benefit plan	Dec. 31, 2021
Retirement Benefits [Abstract]
Employee benefit plan	Employee benefit planThe Company sponsors a 401(k) tax-deferred savings plan for all employees who meet certain eligibility requirements. Participants may contribute, on a pre-tax or post-tax basis, a percentage of their annual compensation, not to exceed a maximum contribution amount pursuant to Section 401(k) of the Internal Revenue Code. The Company match is 100% of the employees’ first contribution of 3%, plus 50% of the next 2% of eligible compensation contributed by the employee, up to a maximum Company match of 4% of compensation for each employee. The Company contributed $0.6 million and $0.2 million for the years ended December 31, 2021 and 2020, respectively.

Acquisitions - Totient Narrative (Details) - USD ($) $ in Thousands		12 Months Ended
	Jun. 04, 2021	Dec. 31, 2021	Dec. 31, 2020
Business Acquisition
Business combination, cash consideration, deferred cash payment, term	1 year
Acquisition-related Costs
Business Acquisition
Net loss applicable to common stockholders and unitholders			$ (900)
Acceleration of SAR and ESPP
Business Acquisition
Net loss applicable to common stockholders and unitholders			(1,600)
Totient
Business Acquisition
Total cash payments to acquire business including milestone payments	$ 55,000
Cash consideration	40,000
Aggregate milestone consideration	15,000
Business combination, cash consideration, deferred cash payment	8,000
Goodwill, purchase accounting adjustments		$ (1,600)
Acquisition costs	$ 900
Net loss applicable to common stockholders and unitholders		$ (113,119)	$ (60,701)
Totient \| Vest On Closing
Business Acquisition
Percentage of shares subject to vest (percent)	25.00%
Totient \| Share Vesting Based On Service
Business Acquisition
Percentage of shares subject to vest (percent)	75.00%
Vesting period	2 years 6 months
Totient \| Common Stock
Business Acquisition
Shares issued as consideration (shares)	2,212,208
Totient \| Common Stock \| Share Vesting Based On Service
Business Acquisition
Vesting rate (months)	6 months

Net loss per share attributable to common stockholders and unitholders

12 Months Ended

Dec. 31, 2021

Earnings Per Share [Abstract]

Net loss per share attributable to common stockholders and unitholders

Basic net loss per share is computed by dividing net loss by the weighted-average number of common shares outstanding during the period.




	2021		2020
Numerator:
Net loss	$	(100,960)	$	(14,353)
Adjustment of redeemable convertible preferred stock and units	—		(34,336)
Cumulative undeclared preferred stock dividends	(2,284)		(780)
Net loss available to common stockholder and unitholders	$	(103,244)	$	(49,469)

Denominator:
Weighted-average common shares and units outstanding	49,685,194		15,494,908

Net loss per share, basic and diluted	$	(2.08)	$	(3.19)

The common stock issuable upon the conversion or exercise of the following dilutive securities has been excluded from the diluted net loss per share calculation because their effect would have been anti-dilutive. Diluted net loss per share, therefore, does not differ from basic net loss per share for the periods presented.

Potentially dilutive securities not included in the calculation of diluted net loss per share because to do so would be anti-dilutive are as follows (in common stock equivalent shares):




	2021	2020
Redeemable convertible preferred stock and units outstanding	25,489,573	45,424,373
Redeemable convertible preferred stock and unit warrants	189,377	307,211

Stock options	6,379,236	1,645,237
Unvested restricted stock	2,616,641	1,111,642

Organization and nature of operations (Details) $ / shares in Units, $ in Millions			1 Months Ended
	Jul. 16, 2021	Oct. 15, 2020 $ / shares	Jul. 31, 2021 USD ($) $ / shares shares	Mar. 31, 2021 shares	Dec. 31, 2021 $ / shares shares	Jul. 26, 2021 shares	Jun. 30, 2021 shares	Dec. 31, 2020 $ / shares shares
Class of Stock
Common stock, shares authorized (in shares)					500,000,000	500,000,000	78,320,000	72,668,200
Shares issued upon conversion of convertible preferred shares (in shares)			46,266,256
Preferred stock, shares authorized (in shares)						10,000,000
Stock split ratio	3.3031
Common stock, par value (usd per share) \| $ / shares		$ 0.0001			$ 0.0001			$ 0.0001
Redeemable Convertible Preferred Stock [Member]
Class of Stock
Preferred stock, shares authorized (in shares)					0			13,845,050
Preferred stock, par value (usd per share) \| $ / shares		$ 0.0001			$ 0.0001			$ 0.0001
Common Units
Class of Stock
Stock split ratio		1
Redeemable Convertible Preferred Units
Class of Stock
Stock split ratio		1
2021 Notes \| Convertible promissory notes
Class of Stock
Shares issued upon conversion of convertible debt (shares)				9,732,593
IPO
Class of Stock
Shares issued and sold (in shares)			14,400,000
Issuance price (usd per share) \| $ / shares			$ 16.00
Proceeds from issuance initial public offering \| $			$ 210.1
Over-Allotment Option
Class of Stock
Shares issued and sold (in shares)			1,900,000

Acquisitions - Denovium Narrative (Details) - USD ($) $ in Thousands	1 Months Ended
	Jan. 31, 2021	Dec. 31, 2021	Dec. 31, 2020
Business Acquisition
Restricted cash		$ 10,513	$ 0
Goodwill		$ 21,335	$ 0
Denovium
Business Acquisition
Total purchase consideration	$ 3,038
Payment of upfront consideration and working capital adjustments	2,500
Restricted cash	2,500
Goodwill	$ 1,055
Denovium \| Common Stock
Business Acquisition
Shares issued as consideration (shares)	1,010,296
Percentage of shares subjected to stock restriction agreement (percent)	80.00%
Shares subjected to stock restriction agreement (shares)	808,238
Vesting period (years)	4 years
Fair value of stock restriction agreement	$ 1,500
Percentage of shares not subjected to stock restriction agreement (percent)	20.00%
Shares not subjected to stock restriction agreement (shares)	202,058

Related party transactions (Details) - USD ($)	3 Months Ended	12 Months Ended
Related party transactions (Details) - USD ($)	Dec. 31, 2021	Dec. 31, 2021	Dec. 31, 2020
Related Party Transaction
Issuance Of Shares Upon Warrant Exercise, Value		$ 93,000
Affiliated Entity \| Common Stock
Related Party Transaction
Issuance of shares upon warrant exercise (in shares)		307,211
Issuance Of Shares Upon Warrant Exercise, Value	$ 100,000
Affiliated Entity \| AGC, Inc.
Related Party Transaction
Revenue from related parties		$ 0	$ 200,000

- Definition

Amount of revenue, fees and commissions earned from transactions between (a) a parent company and its subsidiaries; (b) subsidiaries of a common parent; (c) an entity and trusts for the benefit of employees, for example, but not limited to, pension and profit-sharing trusts that are managed by or under the trusteeship of the entity's management; (d) an entity and its principal, owners, management, or members of their immediate families; and (e) affiliates.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 470
-SubTopic 10
-Section S99
-Paragraph 1B
-Subparagraph (SX 210.13-02(a)(4)(iv))
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Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef
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-Name Accounting Standards Codification
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-Section S99
-Paragraph 1
-Subparagraph (SX 210.6-07.1(c))
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Reference 3: http://www.xbrl.org/2003/role/disclosureRef
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-Name Accounting Standards Codification
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-Subparagraph (SX 210.13-01(a)(4)(iii)(B))
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Reference 4: http://www.xbrl.org/2003/role/disclosureRef
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Reference 5: http://www.xbrl.org/2003/role/disclosureRef
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Reference 6: http://www.xbrl.org/2003/role/disclosureRef
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Reference 7: http://www.xbrl.org/2003/role/disclosureRef
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Reference 8: http://fasb.org/us-gaap/role/ref/legacyRef
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-Name Accounting Standards Codification
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-SubTopic 10
-Section S99
-Paragraph 2
-Subparagraph (SX 210.5-03.1(e))
-URI http://asc.fasb.org/extlink&oid=123367319&loc=SL114868664-224227

+ Details

Income Taxes - Components deferred income tax assets and liabilities (Details) - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020
Deferred tax assets:
Net operating losses	$ 22,508	$ 941
Research and development credits	698	7
Stock-based compensation	1,342	19
Lease liability	2,651	1,157
Accrued expenses	300	3
Gross deferred tax assets	27,499	2,127
Less valuation allowance	(10,481)	(477)
Total deferred tax assets	17,018	1,650
Deferred tax liabilities:
Depreciation and amortization	(15,221)	(520)
Right-of-Use Lease	(2,540)	(1,130)
Gross deferred tax liabilities	(17,761)	(1,650)
Deferred tax liabilities, net	$ (743)	$ 0

Acquisitions - Proforma Revenue (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020
Totient
Business Acquisition, Pro Forma Information
Net loss applicable to common stockholders and unitholders	$ (113,119)	$ (60,701)

Net loss per share attributable to common stockholders and unitholders - Anti-dilutive Securities (Details) - shares	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020
Redeemable Convertible Preferred Stock [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share
Antidilutive securities excluded from computation of earnings per share, amount (in shares)	25,489,573	45,424,373
Redeemable convertible preferred stock and unit warrants
Antidilutive Securities Excluded from Computation of Earnings Per Share
Antidilutive securities excluded from computation of earnings per share, amount (in shares)	189,377	307,211
Stock options
Antidilutive Securities Excluded from Computation of Earnings Per Share
Antidilutive securities excluded from computation of earnings per share, amount (in shares)	6,379,236	1,645,237
Unvested restricted stock
Antidilutive Securities Excluded from Computation of Earnings Per Share
Antidilutive securities excluded from computation of earnings per share, amount (in shares)	2,616,641	1,111,642

Goodwill and Intangibles, net - Schedule of Finite-Lived Intangible Assets (Details) $ in Thousands	Dec. 31, 2021 USD ($)
Finite-Lived Intangible Assets, Net
Gross Assets	$ 57,107
Accumulated Amortization	(2,115)
Net	54,992
Denovium Engine
Finite-Lived Intangible Assets, Net
Gross Assets	2,507
Accumulated Amortization	(473)
Net	2,034
Monoclonal antibody library
Finite-Lived Intangible Assets, Net
Gross Assets	46,300
Accumulated Amortization	(1,325)
Net	44,975
Developed software platform and the related methods patents
Finite-Lived Intangible Assets, Net
Gross Assets	8,300
Accumulated Amortization	(317)
Net	$ 7,983

Income Taxes

12 Months Ended

Dec. 31, 2021

Income Tax Disclosure [Abstract]

Income Taxes

Provision for Income Taxes:

The Company was classified as a partnership, and was therefore a pass-through entity, for U.S. income tax purposes through the LLC Conversion on October 15, 2020. The Company incurred net losses for the years ended December 31, 2021 and 2020.

The significant components of income tax for the years ended December 31 are as follows (in thousands):




	2021		2020
Current
Federal	$	—	$	—
State	2		2
Total current	2		2

Deferred expense/(benefit)
Federal	(7,254)		—
State	(1,647)		—
Total deferred	(8,901)		—

Total	$	(8,899)	$	2

The provision for income taxes results in effective tax rates which are different than the federal income tax statutory rate. The nature of the differences for the years ended December 31, 2021 and 2020 were as follows:




	2021		2020
Expected federal income tax	21.0	%	21.0	%
State income taxes after credits	4.8		4.2
Tax-effect of change in entity status	0.3		(3.7)
Change in valuation allowance	(9.1)		(3.3)
Research and development credits	0.6		0.1
Stock-based compensation	(0.9)		(0.4)
Revaluation of warrant liability	(1.0)		(0.2)
Change in fair value of convertible promissory notes	(6.6)		—
Loss allocable to pre-incorporation period	—		(17.7)
Other	(1.0)		—
Effective tax rate	8.1	%	—	%

Deferred income taxes reflect the net tax effects of temporary differences between the carrying amounts of the assets and liabilities for financial reporting purposes and amounts used for income tax purposes. Significant components of the Company’s deferred income tax assets and liabilities are as follows at December 31, 2021 and 2020 (in thousands):



	2021		2020
Deferred tax assets:
Net operating losses	$	22,508	$	941
Research and development credits	698		7
Stock-based compensation	1,342		19
Lease liability	2,651		1,157
Accrued expenses	300		3
Gross deferred tax assets	27,499		2,127
Less valuation allowance	(10,481)		(477)
Total deferred tax assets	17,018		1,650

Deferred tax liabilities:
Depreciation and amortization	(15,221)		(520)
Right-of-Use Lease	(2,540)		(1,130)
Gross deferred tax liabilities	(17,761)		(1,650)
Deferred tax liabilities, net	$	(743)	$	—

As of December 31, 2021, the Company has remaining federal net operating losses of $86.3 million and has state net operating loss carryforwards of approximately $74.9 million to offset against future taxable income for state tax purposes. Under the Tax Cuts and Jobs Act of 2017 (“TCJA”), federal net operating losses incurred in 2018 and future years may be carried forward indefinitely, but the deductibility of such federal NOLs is subject to an annual limitation. NOLs generated prior to 2018 are eligible to be carried forward up to 20 years. State net operating losses can be carried forward for 5 to 20 years depending on the jurisdiction and will begin to expire in years 2025 to 2040. The company also has Federal research credit carryforwards of approximately $1.4 million that will begin to expire in 2040. We file federal and certain state income tax returns, which provide varying statutes of limitations on assessments. However, because of NOL carryforwards, substantially all tax years since the Company’s incorporation remain open to federal and state tax examination.

In assessing the realization of deferred tax assets, management considers whether it is more likely than not that some portion or all of the deferred assets will be realized. The ultimate realization of the deferred tax assets is dependent upon the generation of future taxable income during the periods in which those temporary differences become deductible. Evaluating the need for a valuation allowance for deferred tax assets often requires judgment and analysis of all the positive and negative evidence available, including cumulative losses in recent years and projected future taxable income, to determine whether all or some portion of the deferred tax assets will not be realized. As of December 31, 2021, the Company has utilized a full valuation allowance to offset the net deferred tax assets as the Company believes it is not more likely than not that the net deferred tax assets will be fully realizable. The valuation allowance increased $10.0 million during the year ended December 31, 2021 and $0.5 million during the year ended December 31, 2020.

Under the provisions of the Internal Revenue Code, certain substantial changes in the company's ownership may result in a limitation on the amount of net operating loss carryforwards and research and development credit carryforwards which could be utilized annually to offset future taxable income and taxes payable. A formal Section 382 study was not performed through December 31, 2021.

We recognize the effect of income tax positions only if those positions are more likely than not of being sustained. We had unrecognized tax benefits of $0.7 million as of December 31, 2021 and no unrecognized tax benefits as of December 31, 2020.

We recognize penalties and interest related to unrecognized tax benefits as a component of income tax expense. As of December 31, 2021 and December 31, 2020, there are no accrued penalties or interest recorded in the financial statements. All unrecognized tax benefits would currently not have an impact on the effective rate if recognized. The following is a reconciliation of our unrecognized tax benefits:



	2021
Balance at January 1	$	—
Additions Based On Tax Positions Related to Current Year	698



Balance at December 31	$	698

- Definition

The entire disclosure for income taxes. Disclosures may include net deferred tax liability or asset recognized in an enterprise's statement of financial position, net change during the year in the total valuation allowance, approximate tax effect of each type of temporary difference and carryforward that gives rise to a significant portion of deferred tax liabilities and deferred tax assets, utilization of a tax carryback, and tax uncertainties information.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 21
-URI http://asc.fasb.org/extlink&oid=121826272&loc=d3e32857-109319

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
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Reference 3: http://www.xbrl.org/2003/role/disclosureRef
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Reference 4: http://www.xbrl.org/2003/role/disclosureRef
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-Name Accounting Standards Codification
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Reference 5: http://www.xbrl.org/2003/role/disclosureRef
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Reference 6: http://www.xbrl.org/2003/role/disclosureRef
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Reference 7: http://www.xbrl.org/2003/role/disclosureRef
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Reference 8: http://www.xbrl.org/2003/role/disclosureRef
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-Name Accounting Standards Codification
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-URI http://asc.fasb.org/extlink&oid=6424122&loc=d3e41874-109331

Reference 9: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 235
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-Paragraph 1
-Subparagraph (SX 210.4-08(h)(2))
-URI http://asc.fasb.org/extlink&oid=120395691&loc=d3e23780-122690

+ Details

Commitment and Contingencies (Details)	Dec. 31, 2021 USD ($)
Standby Letters of Credit
Line of Credit Facility
Maximum borrowing capacity	$ 1,800,000

Summary of significant accounting policies (Policies)	12 Months Ended
Summary of significant accounting policies (Policies)	Dec. 31, 2021
Accounting Policies [Abstract]
Basis of presentation	Basis of presentation The consolidated financial statements are prepared in accordance with US GAAP as defined by the Financial Accounting Standards Board (“FASB”). The consolidated financial statements include the Company’s wholly-owned subsidiaries and entities under its control. The Company has eliminated all intercompany transactions and accounts.
Business combinations	Business combinations The Company utilizes the acquisition method of accounting for business combinations and allocates the purchase price of an acquisition to the various tangible and intangible assets acquired and liabilities assumed based on their estimated fair values. The Company primarily establishes fair value using the replacement cost approach or the income approach based upon a discounted cash flow model. The replacement cost approach measures the value of an asset by the cost to reconstruct or replace it with another of like utility. The income approach requires the use of many assumptions and estimates including future revenues and expenses, as well as discount factors and income tax rates. Other estimates include: •The use of carrying value as a proxy for fair values of fixed assets and liabilities assumed from the target; and •Fair values of intangible assets and contingent consideration. While the Company uses best estimates and assumptions as part of the purchase price allocation process to accurately value assets acquired and liabilities assumed at the business acquisition date, these estimates and assumptions are inherently uncertain and subject to refinement. As a result, during the purchase price measurement period, which is no more than one year from the business acquisition date, the Company may record adjustments to the assets acquired and liabilities assumed, with the corresponding offset to goodwill. Business combinations also require the Company to estimate the useful life of certain intangible assets acquired and this estimate requires significant judgment.
Use of estimates	Use of estimates The preparation of financial statements in accordance with US GAAP requires management to make estimates and assumptions that affect certain reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements and the reported amounts of revenues and expenses during the reporting period. Such estimates include, but are not limited to, revenue recognition including estimated timing of the satisfaction of performance obligations, purchase price allocations in conjunction with business combinations, and the fair value of stock-based compensation awards. The Company bases its estimates on historical experiences, and other relevant factors that it believes to be reasonable under the circumstances. Actual results could differ from those estimates.
Segment information	Segment information The Company operates as a single operating segment. The Company’s chief operating decision maker, its Chief Executive Officer, manages the Company’s operations on a consolidated basis for the purposes of allocating resources, making operating decisions and evaluating performance.
Cash, cash equivalents	The Company considers all highly liquid investments with an original maturity of three months or less to be cash equivalents.
Restricted cash	Restricted cash represents amounts pledged as collateral for future property lease payments via standby letters of credit (see Note 8: Commitments and contingencies) and amounts held in escrow related to acquisitions by the Company (see Note 3: Acquisitions).
Accounts receivable	Accounts receivableAccounts receivable consists of amounts due from partners for services performed. The Company reviews accounts receivable for credit impairment and regularly analyzes the status of significant past due receivables to determine if any will potentially be uncollectible to estimate the amount of allowance necessary to reduce accounts receivable to its estimated net realizable value.
Fair value of financial instruments	Fair value of financial instruments Certain assets and liabilities are carried at fair value under US GAAP and consist principally of a fee in-lieu of warrant issuance, a warrant to purchase convertible preferred stock and convertible promissory notes. The carrying amounts of cash equivalents, accounts payable, and accrued liabilities approximate their related fair values due to the short-term nature of these instruments. None of the Company’s non-financial assets or liabilities are recorded at fair value on a recurring basis. As permitted under Accounting Standards Codification (“ASC”) 825, Financial Instruments, (“ASC 825”), the Company has elected the fair value option to account for its convertible promissory notes issued during the year ended December 31, 2021. In accordance with ASC 825, the Company records these convertible promissory notes at fair value on its consolidated balance sheet. Changes in fair value of the warrant to purchase convertible preferred stock and the convertible promissory notes are recorded in the consolidated statements of operations and comprehensive loss. As a result of applying the fair value option, direct costs and fees related to the convertible promissory notes were recognized as incurred and not deferred. There are significant judgments and estimates inherent in the determination of the fair value of these liabilities. If the Company had made different assumptions including, among others, those related to the timing and probability of various corporate scenarios, discount rates, volatilities and exit valuations, the carrying values of the fee in lieu of warrant, warrant liability, and net loss and net loss per common share could have been significantly different.
Concentration risk	Concentration riskFinancial instruments that potentially subject the Company to concentrations of credit risk consist principally of cash and cash equivalents, restricted cash, and receivables under development arrangements. The Company maintains its cash and cash equivalents and restricted cash in bank accounts, which at times may exceed federally insured limits.
Supplies	Supplies Supplies, comprised principally of supplies and other materials used in the lab, are stated at the lower of cost or net realizable value and using the first-in, first-out method, applied on a consistent basis. The supplies inventory is included in prepaid expenses and other current assets on the consolidated balance sheet.
Property and equipment, net	Property and equipment, net Property and equipment are stated at cost less accumulated depreciation and amortization. Additions and improvements to property and equipment are capitalized. The costs of maintenance and repairs are expensed as incurred. Depreciation and amortization are computed using the straight-line method over the estimated useful lives of the underlying assets, which vary from 3 to 7 years. Leasehold improvements are amortized over the shorter of the term of the lease or the estimated useful lives of the assets. When assets are sold or otherwise disposed of, the cost and related accumulated depreciation or amortization are removed from their respective accounts, and the resulting gain or loss is reported as income or expense in the consolidated statements of operations and comprehensive loss.
Impairment of long-lived assets	Impairment of long-lived assetsManagement reviews long-lived assets for possible impairment whenever events or circumstances indicate that the carrying amount of such assets may not be recoverable. Recoverability is measured by comparison of the carrying amount to the future undiscounted net cash flows expected to result from the use of the asset and its eventual disposition. If these estimated cash flows were less than the carrying amount of the asset, an impairment loss would be recognized in order to write down the asset to its estimated fair value.
Goodwill	Goodwill Goodwill is evaluated for impairment on an annual basis as of October 1, or more frequently if an indicator of impairment is present. As part of the impairment evaluation, the Company may elect to perform an assessment of qualitative factors. If this qualitative assessment indicates that it is more likely than not that the fair value of the reporting unit that includes the goodwill is less than its carrying value, then a quantitative impairment test would be prepared to compare this fair value to the carrying value and record an impairment charge if the carrying value exceeds the fair value.
Redeemable convertible preferred units and stock warrant liability	Redeemable convertible preferred units and stock warrant liabilityOutstanding warrants that were related to the Company’s redeemable convertible preferred units and redeemable convertible preferred stock were classified as liabilities on the consolidated balance sheets. As the warrants were exercisable for redeemable convertible preferred units and redeemable convertible preferred stock, the Company has recognized a liability for the fair value of its warrants on the consolidated balance sheets upon issuance and subsequently remeasures the liability to fair value at the end of each reporting period until the earlier of the expiration or exercise of the warrants.
Revenue recognition	Revenue recognition The Company recognizes revenue as control of its products and services are transferred to its customers in an amount that reflects the consideration expected to be received in exchange for those products and services. This process involves identifying the contract with a customer, determining the performance obligations in the contract, determining the contract price, allocating the contract price to the distinct performance obligations in the contract, and recognizing revenue when or as the performance obligations are satisfied. A performance obligation is considered distinct from other obligations in a contract when it provides a benefit to the customer either on its own or together with other resources that are readily available to the customer and is separately identified in the contract. The Company considers a performance obligation satisfied once control of a good or service has been transferred to the customer, meaning the customer has the ability to use and obtain the benefit of the good or service. Technology development revenue includes revenue associated to the development and technology readiness phases of technology development agreements. The Company refers to its customers as “partners” when describing their relationship in an agreement. Technology development revenue The Company’s Technology Development Agreements (“TDAs”) generally include multiple phases of drug discovery and/or Cell Line Development (“CLD”) such as library design, assay development, strain screening, fermentation optimization, purification, and analytics that all represent a single performance obligation. These agreements may include options for additional goods and services such as readying the technology to transfer to the partner and licensing terms. The transaction prices for these arrangements include fixed and variable consideration for the single performance obligation as well as variable consideration for success-based achievements. Any variable consideration is constrained to the extent that it is probable that a significant reversal of cumulative revenue will not occur. Depending on the specific terms of the arrangement, the Company either recognizes revenue over time or at a point in time. While there is no alternative use to the Company for the asset created, the agreement’s terms vary as to whether an enforceable right to payment exists for performance completed as of that date. Primarily all of the Company’s contracts with its partners include an enforceable right to payment. The Company measures progress toward the completion of the performance obligations satisfied over time using an input method based on an overall estimate of the effort incurred to date at each reporting period to satisfy a performance obligation. This method provides an appropriate depiction of completed progress toward fulfilling its performance obligations for each respective arrangement. In certain technology development agreements that require a portion of the contract consideration to be received in advance at the commencement of the contract, such advance payment is initially recorded as a contract liability.
Income taxes	Income taxes Prior to the LLC Conversion, all income tax effects of the Company's operations were passed through to its members individually. Accordingly, the accompanying financial statements do not include any income tax effects for the Company prior to the LLC Conversion date, and the Company had no unrecognized income tax benefits, nor any interest or penalties associated with unrecognized income tax benefits, accrued or expensed as of and for the period from January 1, 2020 through October 15, 2020. Following the LLC Conversion, the Company accounts for income taxes using the asset and liability method whereby deferred tax asset and liability accounts are determined based on differences between financial reporting and tax bases of assets and liabilities and are measured using the enacted tax rates and laws that are currently in effect. Valuation allowances are established where necessary to reduce deferred tax assets to the amounts expected to be realized. The Company files income tax returns in the federal and various state tax jurisdictions. The Company recognizes interest and penalties related to income tax matters as a component of tax expense.
Leases	Leases At the inception of a contractual arrangement, the Company determines whether the contract contains a lease by assessing whether there is an identified asset and whether the contract conveys the right to control the use of the identified asset in exchange for consideration over a period of time. If both criteria are met, the Company records the associated lease liability and corresponding right-of-use asset upon commencement of the lease using the implicit rate or a discount rate based on a credit adjusted secured borrowing rate commensurate with the term of the lease. The Company additionally evaluates leases at their inception to determine if they are to be accounted for as an operating lease or a finance lease. Operating lease assets represent a right to use an underlying asset for the lease term and operating lease liabilities represent an obligation to make lease payments arising from the lease. Operating lease obligations with a term greater than one year and their corresponding right-of-use assets are recognized on the consolidated balance sheet at the commencement date of the lease based on the present value of lease payments over the expected lease term. Certain adjustments to the right-of-use asset may be required for items such as initial direct costs paid or incentives received. As the Company’s operating leases do not typically provide an implicit rate, the Company utilizes the appropriate incremental borrowing rate, determined as the rate of interest that the Company would have to pay to borrow on a collateralized basis over a similar term and in a similar economic environment. The lease cost is recognized on a straight-line basis over the lease term and variable lease payments are recognized as operating expenses in the period in which the obligation for those payments is incurred. Variable lease payments primarily include common area maintenance, utilities, real estate taxes, insurance and other operating costs that are passed on from the lessor in proportion to the space leased by the Company. The Company accounts for its finance leases by calculating an implied interest rate in the lease contract and recognizing a finance lease right of use asset and lease liability. The right of use asset is recognized in property and equipment, net, in the asset category in which the underlying asset relates. The lease liability is recognized in the consolidated balance sheet as a finance lease obligation.
Research and development expenses	Research and development expenses Research and development expenses include the cost of materials, personnel-related costs (comprised of salaries, benefits and share-based compensation), consulting fees and allocated facility costs associated with both the Company’s execution of technology development agreements and collaboration agreements, as well as ongoing development of the Integrated Drug Creation Platform and other technologies. Allocated facility costs include facility occupancy and information technology costs. The Company derives improvements to its platform from both types of activities. The Company has not historically tracked its research and development expenses on a partner-by-partner basis or on a program-by-program basis.
Stock-based compensation	Stock-based compensationStock-based compensation includes compensation expense for incentive units, restricted stock, and stock option grants to employees and is measured on the grant date based on the fair value of the award and recognized on a straight-line basis over the requisite service period. The fair value of options to purchase common stock are measured using the Black-Scholes option-pricing model. The Company accounts for forfeitures as they occur. Prior to the LLC Conversion, the Company also granted phantom units which due to the presence of an exercise condition contingent upon a liquidity event, the Company determined that it was not probable that the phantom units would become exercisable.
Net Loss Per Share Attributable to Common Stockholders and Unitholders	Net Loss Per Share Attributable to Common Stockholders and Unitholders Basic and diluted net loss per common share is calculated by dividing net loss by the weighted-average number of common shares outstanding during the period, without consideration for common stock equivalents. The Company was in a loss position for all periods presented, therefore basic net loss per share and diluted net loss per share are the same for all periods as the inclusion of all potential common securities outstanding would have been anti-dilutive.
Recently Adopted Accounting Pronouncements and Recently issued accounting pronouncements, not yet adopted	Recently adopted accounting pronouncements In August 2020, the FASB issued ASU No. 2020-06, Debt — Debt with Conversion and Other Options (Subtopic 470-20) and Derivatives and Hedging — Contracts in Entity’s Own Equity (Subtopic 815-40) (“ASU No. 2020-06”). The new guidance eliminates two of the three models in ASC 470-20 that require separating embedded conversion features from convertible instruments. As a result, only conversion features accounted for under the substantial premium model in ASC 470-20 and those that require bifurcation in accordance with ASC 815-15 will be accounted for separately. For contracts in an entity’s own equity, the new guidance eliminates some of the requirements in ASC 815-40 for equity classification. The guidance also addresses how convertible instruments are accounted for in the diluted earnings per share calculation and requires enhanced disclosures about the terms of convertible instruments and contracts in an entity’s own equity. ASU 2020-06 is effective for the Company after December 15, 2023. Early adoption is permitted for fiscal periods beginning after December 15, 2020. The Company adopted this standard as of January 1, 2021, and the adoption of this standard did not have a material impact on its consolidated financial statements. Recently issued accounting pronouncements, not yet adopted In December 2019, the FASB issued amended guidance on the accounting and reporting of income taxes. The guidance is intended to simplify the accounting for income taxes by removing exceptions related to certain intraperiod tax allocations and deferred tax liabilities; clarifying guidance primarily related to evaluating the step-up tax basis for goodwill in a business combination; and reflecting enacted changes in tax laws or rates in the annual effective tax rate. The amended guidance is effective for fiscal years beginning after December 15, 2021, and interim periods within fiscal years beginning after December 15, 2022. Early adoption is permitted. The application of the amendments in the new guidance are to be applied on a retrospective basis, on a modified retrospective basis through a cumulative-effect adjustment to retained earnings or prospectively, depending on the amendment. The Company is currently evaluating the impact of the potential adoption of this guidance on its consolidated financial statements.

Property and equipment, net - Narratives (Details) - USD ($) $ in Millions	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020
Property, Plant and Equipment [Abstract]
Depreciation expense	$ 4.5	$ 1.1

Redeemable convertible preferred stock

12 Months Ended

Dec. 31, 2021

Temporary Equity Disclosure [Abstract]

Redeemable convertible preferred stock

Redeemable Convertible Preferred Stock

Prior to its conversion to common stock in connection with the Company’s IPO, the convertible preferred stock was classified as temporary equity on the accompanying consolidated balance sheets since the shares contained certain redemption features that were not solely within the control of the Company. The Company had not previously accreted the convertible preferred stock to its redemption value since the shares were not redeemable and redemption was not deemed to be probable.

The following table summarizes the authorized, issued, and outstanding redeemable convertible preferred stock of the Company as of December 31, 2020 (in thousands, except share and per share data):


	December 31, 2020
	Shares Authorized	Shares Issued and Outstanding	Issuance Price per Share		Net Proceeds		Liquidation Preference
Convertible Preferred Stock:
Junior	1,573,547	1,573,547	$	1.00	$	1,462	$	1,989
Series A-1	2,793,007	2,700,000	1.00		2,700		3,453
Series A-2	1,500,000	1,500,000	1.00		1,500		1,885
Series B	1,372,549	1,372,549	1.53		2,065		2,526
Series C	1,760,252	1,760,252	6.95		11,979		14,110
Series D	1,532,176	1,532,176	9.79		14,951		15,852
Series E	3,313,519	3,313,519	19.62		64,709		163,280
Total convertible preferred stock	13,845,050	13,752,043			$	99,366	$	203,095

Immediately prior to the completion of the IPO, all shares of redeemable convertible preferred stock then outstanding were converted into 46,266,256 shares of common stock.

Preferred stock warrants

As part of the Class A-1 funding in 2016, a warrant for the purchase of 93,007 Class A-1 Preferred Units at an exercise price of $1 per unit and exercisable at any time before April 2026 was granted to an investor. This warrant was exchanged for a warrant to purchase Class A-1 preferred stock at equivalent terms in October 2020. Because the underlying shares are redeemable for conditions outside of the Company’s control, the warrant was classified within other long-term liabilities on the consolidated balance sheets and recognized at fair value at each reporting period with the change in fair value recorded in other expense on the consolidated statement of operations and comprehensive loss prior to the IPO. The balance was included in other long-term liabilities on the consolidated balance sheet prior to the IPO. The warrant was converted into a warrant to purchase 307,211 shares of the Company’s common stock upon the closing of the IPO. The warrant holder fully exercised the warrant to purchase common stock for cash during the year ended December 31, 2021 following the IPO.

Acquisitions - Finite-lived Intangible Assets Acquired (Details) - USD ($) $ in Thousands		1 Months Ended
	Jun. 04, 2021	Jan. 31, 2021
Totient
Business Acquisition
Intangible assets	$ 54,600
Totient \| Minimum \| Measurement Input, Discount Rate \| Valuation Technique, Discounted Cash Flow
Business Acquisition
Intangible assets measurement input (percent)	18.00%
Totient \| Maximum \| Measurement Input, Discount Rate \| Valuation Technique, Discounted Cash Flow
Business Acquisition
Intangible assets measurement input (percent)	23.00%
Totient \| Monoclonal antibody library
Business Acquisition
Intangible assets	$ 46,300
Estimated Amortization Period (years)	20 years
Totient \| Developed software platform and the related methods patents
Business Acquisition
Intangible assets	$ 8,300
Estimated Amortization Period (years)	15 years
Denovium
Business Acquisition
Intangible assets		$ 2,507
Denovium \| Denovium Engine
Business Acquisition
Intangible assets		$ 2,507
Estimated Amortization Period (years)		5 years

Fair Value Measurements (Tables)

12 Months Ended

Dec. 31, 2021

Fair Value Disclosures [Abstract]

Schedule of Fair Value, Liabilities Measured on Recurring Basis

The following table summarizes the Company’s assets and liabilities measured at fair value on a recurring basis as of December 31, 2021 and December 31, 2020 (in thousands):



	December 31, 2021
	Level 1		Level 2		Level 3		Total
Assets:
Equity securities without RDFV	$	—	$	—	$	1,200	$	1,200
Total assets	$	—	$	—	$	1,200	$	1,200
Liabilities:



Contingent consideration	$	—	$	—	$	12,000	$	12,000
Total liabilities	$	—	$	—	$	12,000	$	12,000



	December 31, 2020
	Level 1		Level 2		Level 3		Total



Liabilities:
Fee in-lieu of warrant	$	—	$	—	$	22	$	22

Preferred stock warrant liability	—		—		698		698

Total liabilities	$	—	$	—	$	720	$	720

Fair Value Using Significant Unobservable Inputs (Level 3)

The following table provides reconciliation for all liabilities measured at fair value using significant unobservable inputs (Level 3) for the year ended December 31, 2021 (in thousands):



	Fee in-lieu of warrant		Convertible promissory notes		Preferred stock warrant liability		Contingent consideration		Total liabilities
Balance at December 31, 2020	$	22	$	—	$	698	$	—	$	720
Fair value at issuance	—		125,000		—		12,000		137,000
Change in fair value during 2021	174		30,722		4,124		—		35,020
Conversion or payment at IPO	(196)		(155,722)		(4,822)		—		(160,740)
Balance at December 31, 2021	$	—	$	—	$	—	$	12,000	$	12,000

Stock-based compensation - Unvested Rollforward (Details)	12 Months Ended
	Dec. 31, 2021 $ / shares shares
Restricted stock
Nonvested, Number of Shares
Beginning balance, unvested, shares	1,111,642
Granted, shares	2,441,129
Vested, shares	(967,101)
Ending balance, unvested, shares	2,585,670
Phantom Units
Nonvested, Number of Shares
Beginning balance, unvested, shares	1,202,435
Granted, shares	0
Vested, shares	0
Exchange of phantom units for cash payment rights, SARs, and/or stock options, shares	(1,202,435)
Ending balance, unvested, shares	0
Nonvested, Weighted Average Strike Price
Beginning balance unvested, usd per share \| $ / shares	$ 0.47
Granted, usd per share \| $ / shares	0
Vested, usd per share \| $ / shares	0
Exchange of phantom units for cash payment rights, SARs, and/or stock options, usd per share \| $ / shares	0.47
Ending balance unvested, usd per share \| $ / shares	$ 0

Summary of significant accounting policies - Deferred Offering Costs (Details) $ in Thousands	Jul. 31, 2021 USD ($)
IPO
Deferred offering costs	$ 3,766

Stock-based compensation - Stock Option Narratives (Details) - USD ($) $ / shares in Units, $ in Millions	1 Months Ended	12 Months Ended
	Jun. 30, 2021	Dec. 31, 2021	Dec. 31, 2020	Jul. 31, 2021
Share-based Compensation Arrangement by Share-based Payment Award
Fair value of vested options		$ 2.4	$ 0.1
Exercised		$ 1.4
Share-based compensation arrangement by share-based payment award, options, outstanding, number (in shares)		7,757,401	1,706,339
Share-based compensation arrangement by share-based payment award, options, outstanding, weighted average exercise price (usd per share)		$ 3.72	$ 1.10
2020 Plan
Share-based Compensation Arrangement by Share-based Payment Award
Additional shares authorized for issuance (shares)	11,980,029
2021 Plan
Share-based Compensation Arrangement by Share-based Payment Award
Shares available for grant (shares)		7,473,403		8,133,750
2021 ESPP
Share-based Compensation Arrangement by Share-based Payment Award
Shares authorized, shares				903,750
Stock options \| 2020 Plan
Share-based Compensation Arrangement by Share-based Payment Award
Weighted average grant date fair value of shares granted (usd per share)		$ 4.28	$ 0.83
Share based compensation expense not yet recognized, options		$ 24.6
Share based compensation expense not yet recognized, recognition period (years)		3 years 4 months 24 days
Stock options \| 2020 Plan \| Tranche One
Share-based Compensation Arrangement by Share-based Payment Award
Vesting percentage (percent)		25.00%
Vesting period (years)		1 year
Stock options \| 2020 Plan \| Tranche Two
Share-based Compensation Arrangement by Share-based Payment Award
Vesting period (years)		3 years
Certain options \| 2020 Plan \| Tranche Two \| Minimum
Share-based Compensation Arrangement by Share-based Payment Award
Vesting period (years)		2 years
Certain options \| 2020 Plan \| Tranche Two \| Maximum
Share-based Compensation Arrangement by Share-based Payment Award
Vesting period (years)		4 years
SARs \| 2020 Plan
Share-based Compensation Arrangement by Share-based Payment Award
Vesting period (years)		4 years
SARs \| 2020 And 2021 Plan
Share-based Compensation Arrangement by Share-based Payment Award
Share based compensation expense not yet recognized, options		$ 0.7
Share based compensation expense not yet recognized, recognition period (years)		3 years 6 months
Share-based compensation arrangement by share-based payment award, options, outstanding, number (in shares)		100,881
Share-based compensation arrangement by share-based payment award, options, outstanding, weighted average exercise price (usd per share)		$ 4.97
Deferred compensation liability, classified, noncurrent		$ 0.1

Goodwill and Intangibles, net

12 Months Ended

Dec. 31, 2021

Goodwill and Intangible Assets Disclosure [Abstract]

Goodwill and Intangibles, net

The roll forward of goodwill was as follows (in thousands):



Balance, December 31, 2020	$	—
Goodwill acquired related to acquisition of Denovium	1,055
Goodwill acquired related to acquisition of Totient	20,280
Balance, December 31, 2021	$	21,335

The Company performed its annual goodwill impairment test on October 1, 2021 utilizing the qualitative assessment allowable under ASC 350 Intangibles – Goodwill and Other to determine whether it is more likely than not that the fair value of a reporting unit is less than its carrying value. This qualitative assessment may include, but is not limited to, reviewing factors such as macroeconomic considerations, industry and market trends, cost factors, entity-specific financial performance and other events, such as changes in the Company’s management, strategy and primary user base. If based on a review of qualitative factors, it is more likely than not that the fair value of a reporting unit is less than its carrying value, a quantitative impairment test is performed by comparing the fair value of a reporting unit with its carrying amount. Based on our review of the qualitative factors, the Company determined that a quantitative impairment analysis was not necessary. Based on the results of the Company’s annual impairment test, we concluded that goodwill was not impaired.

There were no impairment losses netted against the goodwill balance at any date.

Intangible assets consisted of the following:



	December 31, 2021
	Gross Assets		Accumulated Amortization		Net
Denovium Engine	2,507		(473)		2,034
Monoclonal antibody library	46,300		(1,325)		44,975
Developed software platform and the related methods patents	8,300		(317)		7,983
Intangible assets, net	$	57,107	$	(2,115)	$	54,992

There was no balance of intangible assets, or related amortization expense, for the year ended December 31, 2020. Amortization expense related to intangible assets was $2.1 million for the year ended December 31, 2021 and is reflected within depreciation and amortization expense on the consolidated statement of operations and comprehensive loss.

At December 31, 2021, amortization expense on intangible assets is estimated to be as follows for each of the next five years:



Years Ending December 31:
2022	$	3,370
2023	3,370
2024	3,370
2025	3,370
2026	2,897
Thereafter	38,615
	$	54,992

Employee benefit plan (Details) - USD ($) $ in Millions	12 Months Ended
Employee benefit plan (Details) - USD ($) $ in Millions	Dec. 31, 2021	Dec. 31, 2020
Retirement Benefits [Abstract]
Defined contribution plan, employer matching contribution, percent of match, tier one	100.00%
Defined contribution plan, employee matching contribution, threshold, tier one	3.00%
Defined contribution plan, employer matching contribution, percent of match, tier two	50.00%
Defined contribution plan, employee matching contribution, threshold, tier two	2.00%
Defined contribution plan, maximum annual contributions per employee, percent	4.00%
Defined benefit plan, plan assets, contributions by employer	$ 0.6	$ 0.2

- Definition

Amount of contribution received by defined benefit plan from employer which increases plan assets.

+ References + Details

Income Taxes (Tables)

12 Months Ended

Dec. 31, 2021

Income Tax Disclosure [Abstract]

Schedule of Components of Income Tax Expense (Benefit)

The significant components of income tax for the years ended December 31 are as follows (in thousands):




	2021		2020
Current
Federal	$	—	$	—
State	2		2
Total current	2		2

Deferred expense/(benefit)
Federal	(7,254)		—
State	(1,647)		—
Total deferred	(8,901)		—

Total	$	(8,899)	$	2

Schedule of Effective Income Tax Rate Reconciliation




	2021		2020
Expected federal income tax	21.0	%	21.0	%
State income taxes after credits	4.8		4.2
Tax-effect of change in entity status	0.3		(3.7)
Change in valuation allowance	(9.1)		(3.3)
Research and development credits	0.6		0.1
Stock-based compensation	(0.9)		(0.4)
Revaluation of warrant liability	(1.0)		(0.2)
Change in fair value of convertible promissory notes	(6.6)		—
Loss allocable to pre-incorporation period	—		(17.7)
Other	(1.0)		—
Effective tax rate	8.1	%	—	%

Schedule of Deferred Tax Assets and Liabilities

Significant components of the Company’s deferred income tax assets and liabilities are as follows at December 31, 2021 and 2020 (in thousands):



	2021		2020
Deferred tax assets:
Net operating losses	$	22,508	$	941
Research and development credits	698		7
Stock-based compensation	1,342		19
Lease liability	2,651		1,157
Accrued expenses	300		3
Gross deferred tax assets	27,499		2,127
Less valuation allowance	(10,481)		(477)
Total deferred tax assets	17,018		1,650

Deferred tax liabilities:
Depreciation and amortization	(15,221)		(520)
Right-of-Use Lease	(2,540)		(1,130)
Gross deferred tax liabilities	(17,761)		(1,650)
Deferred tax liabilities, net	$	(743)	$	—

Schedule of Unrecognized Tax Benefits

The following is a reconciliation of our unrecognized tax benefits:



	2021
Balance at January 1	$	—
Additions Based On Tax Positions Related to Current Year	698



Balance at December 31	$	698

Goodwill and Intangibles, net - Schedule of Goodwill (Details) $ in Thousands	12 Months Ended
	Dec. 31, 2021 USD ($)
Goodwill
Beginning balance	$ 0
Ending balance	21,335
Denovium
Goodwill
Goodwill, acquired during period	1,055
Totient
Goodwill
Goodwill, acquired during period	$ 20,280

Long-term debt and other borrowings - Schedule of Maturities of Long-term Debt (Details) $ in Thousands	Dec. 31, 2021 USD ($)
Years ending December 31:
2022	$ 2,400
2023	1,150
2024	0
2025	0
2026	0
Total principal, including final fee	3,550
Less: amount representing debt discounts and issuance costs	(26)
Total long-term debt	$ 3,524

- Definition

Amount, after unamortized (discount) premium and debt issuance costs, of long-term debt. Includes, but not limited to, notes payable, bonds payable, debentures, mortgage loans and commercial paper. Excludes capital lease obligations.

+ References + Details

Redeemable convertible preferred stock (Details) $ / shares in Units, $ in Thousands	12 Months Ended
	Dec. 31, 2020 USD ($) $ / shares shares
Redeemable Convertible Preferred Stock [Member]
Class of Stock
Shares Authorized (in shares)	13,845,050
Shares Issued (in shares)	13,752,043
Shares outstanding (in shares)	13,752,043
Net Proceeds \| $	$ 99,366
Liquidation Preference \| $	$ 203,095
Junior
Class of Stock
Shares Authorized (in shares)	1,573,547
Shares Issued (in shares)	1,573,547
Shares outstanding (in shares)	1,573,547
Issuance price (usd per share) \| $ / shares	$ 1.00
Net Proceeds \| $	$ 1,462
Liquidation Preference \| $	$ 1,989
Series A-1
Class of Stock
Shares Authorized (in shares)	2,793,007
Shares Issued (in shares)	2,700,000
Shares outstanding (in shares)	2,700,000
Issuance price (usd per share) \| $ / shares	$ 1.00
Net Proceeds \| $	$ 2,700
Liquidation Preference \| $	$ 3,453
Series A-2
Class of Stock
Shares Authorized (in shares)	1,500,000
Shares Issued (in shares)	1,500,000
Shares outstanding (in shares)	1,500,000
Issuance price (usd per share) \| $ / shares	$ 1.00
Net Proceeds \| $	$ 1,500
Liquidation Preference \| $	$ 1,885
Series B
Class of Stock
Shares Authorized (in shares)	1,372,549
Shares Issued (in shares)	1,372,549
Shares outstanding (in shares)	1,372,549
Issuance price (usd per share) \| $ / shares	$ 1.53
Net Proceeds \| $	$ 2,065
Liquidation Preference \| $	$ 2,526
Series C
Class of Stock
Shares Authorized (in shares)	1,760,252
Shares Issued (in shares)	1,760,252
Shares outstanding (in shares)	1,760,252
Issuance price (usd per share) \| $ / shares	$ 6.95
Net Proceeds \| $	$ 11,979
Liquidation Preference \| $	$ 14,110
Series D
Class of Stock
Shares Authorized (in shares)	1,532,176
Shares Issued (in shares)	1,532,176
Shares outstanding (in shares)	1,532,176
Issuance price (usd per share) \| $ / shares	$ 9.79
Net Proceeds \| $	$ 14,951
Liquidation Preference \| $	$ 15,852
Series E
Class of Stock
Shares Authorized (in shares)	3,313,519
Shares Issued (in shares)	3,313,519
Shares outstanding (in shares)	3,313,519
Issuance price (usd per share) \| $ / shares	$ 19.62
Net Proceeds \| $	$ 64,709
Liquidation Preference \| $	$ 163,280

Stock-based compensation - Phantom Units Narratives (Details) - USD ($) $ / shares in Units, $ in Millions	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020
Share-based Compensation Arrangement by Share-based Payment Award
Issuance price (usd per share)	$ 8.20
Phantom Units
Share-based Compensation Arrangement by Share-based Payment Award
Shares outstanding (shares)	0	1,202,435
2020 Plan \| Phantom Units \| Tranche One
Share-based Compensation Arrangement by Share-based Payment Award
Vesting percentage (percent)	25.00%
Vesting period (years)	1 year
Vesting percentage in liquidity event (percent)	100.00%
2020 Plan \| Phantom Units \| Tranche Two
Share-based Compensation Arrangement by Share-based Payment Award
Vesting period (years)	3 years
2020 Plan \| SARs
Share-based Compensation Arrangement by Share-based Payment Award
Vesting period (years)	4 years
Shares outstanding (shares)	394,736
Intrinsic value, shares outstanding	$ 3.2

Redeemable convertible preferred stock - Narratives (Details) - $ / shares	12 Months Ended
	Dec. 31, 2021	Jul. 31, 2021	Dec. 31, 2016
Class of Stock
Shares issued upon conversion of convertible preferred shares (in shares)		46,266,256
Series A-1
Class of Stock
Class of warrant or right, number of securities called by warrants or rights (in shares)			93,007
Class of warrant or right, exercise price of warrants or rights (usd per share)			$ 1
Common Stock \| Affiliated Entity
Class of Stock
Issuance of shares upon warrant exercise (in shares)	307,211

Summary of significant accounting policies	12 Months Ended
Summary of significant accounting policies	Dec. 31, 2021
Accounting Policies [Abstract]
Summary of significant accounting policies	Summary of significant accounting policies Basis of presentation The consolidated financial statements are prepared in accordance with US GAAP as defined by the Financial Accounting Standards Board (“FASB”). The consolidated financial statements include the Company’s wholly-owned subsidiaries and entities under its control. The Company has eliminated all intercompany transactions and accounts. Emerging growth company The Company is an “emerging growth company,” as defined in Section 2(a) of the Securities Act, as modified by the Jumpstart Our Business Startups Act of 2012 (the “JOBS Act”), and it may take advantage of certain exemptions from various reporting requirements that are applicable to other public companies that are not emerging growth companies including, but not limited to, not being required to comply with the independent registered public accounting firm attestation requirements of Section 404 of the Sarbanes-Oxley Act of 2002, reduced disclosure obligations regarding executive compensation in its periodic reports and proxy statements, and exemptions from the requirements of holding a nonbinding advisory vote on executive compensation and stockholder approval of any golden parachute payments not previously approved. Business combinations The Company utilizes the acquisition method of accounting for business combinations and allocates the purchase price of an acquisition to the various tangible and intangible assets acquired and liabilities assumed based on their estimated fair values. The Company primarily establishes fair value using the replacement cost approach or the income approach based upon a discounted cash flow model. The replacement cost approach measures the value of an asset by the cost to reconstruct or replace it with another of like utility. The income approach requires the use of many assumptions and estimates including future revenues and expenses, as well as discount factors and income tax rates. Other estimates include: •The use of carrying value as a proxy for fair values of fixed assets and liabilities assumed from the target; and •Fair values of intangible assets and contingent consideration. While the Company uses best estimates and assumptions as part of the purchase price allocation process to accurately value assets acquired and liabilities assumed at the business acquisition date, these estimates and assumptions are inherently uncertain and subject to refinement. As a result, during the purchase price measurement period, which is no more than one year from the business acquisition date, the Company may record adjustments to the assets acquired and liabilities assumed, with the corresponding offset to goodwill. Business combinations also require the Company to estimate the useful life of certain intangible assets acquired and this estimate requires significant judgment. Use of estimates The preparation of financial statements in accordance with US GAAP requires management to make estimates and assumptions that affect certain reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements and the reported amounts of revenues and expenses during the reporting period. Such estimates include, but are not limited to, revenue recognition including estimated timing of the satisfaction of performance obligations, purchase price allocations in conjunction with business combinations, and the fair value of stock-based compensation awards. The Company bases its estimates on historical experiences, and other relevant factors that it believes to be reasonable under the circumstances. Actual results could differ from those estimates. Segment information The Company operates as a single operating segment. The Company’s chief operating decision maker, its Chief Executive Officer, manages the Company’s operations on a consolidated basis for the purposes of allocating resources, making operating decisions and evaluating performance. Cash, cash equivalents and restricted cash The Company considers all highly liquid investments with an original maturity of three months or less to be cash equivalents. Restricted cash represents amounts pledged as collateral for future property lease payments via standby letters of credit (see Note 8: Commitments and contingencies) and amounts held in escrow related to acquisitions by the Company (see Note 3: Acquisitions). Accounts receivable Accounts receivable consists of amounts due from partners for services performed. The Company reviews accounts receivable for credit impairment and regularly analyzes the status of significant past due receivables to determine if any will potentially be uncollectible to estimate the amount of allowance necessary to reduce accounts receivable to its estimated net realizable value. To date, no allowance has been necessary. See contract asset discussion below regarding unbilled receivables. Fair value of financial instruments Certain assets and liabilities are carried at fair value under US GAAP and consist principally of a fee in-lieu of warrant issuance, a warrant to purchase convertible preferred stock and convertible promissory notes. The carrying amounts of cash equivalents, accounts payable, and accrued liabilities approximate their related fair values due to the short-term nature of these instruments. None of the Company’s non-financial assets or liabilities are recorded at fair value on a recurring basis. As permitted under Accounting Standards Codification (“ASC”) 825, Financial Instruments, (“ASC 825”), the Company has elected the fair value option to account for its convertible promissory notes issued during the year ended December 31, 2021. In accordance with ASC 825, the Company records these convertible promissory notes at fair value on its consolidated balance sheet. Changes in fair value of the warrant to purchase convertible preferred stock and the convertible promissory notes are recorded in the consolidated statements of operations and comprehensive loss. As a result of applying the fair value option, direct costs and fees related to the convertible promissory notes were recognized as incurred and not deferred. There are significant judgments and estimates inherent in the determination of the fair value of these liabilities. If the Company had made different assumptions including, among others, those related to the timing and probability of various corporate scenarios, discount rates, volatilities and exit valuations, the carrying values of the fee in lieu of warrant, warrant liability, and net loss and net loss per common share could have been significantly different. Concentration risk Financial instruments that potentially subject the Company to concentrations of credit risk consist principally of cash and cash equivalents, restricted cash, and receivables under development arrangements. The Company maintains its cash and cash equivalents and restricted cash in bank accounts, which at times may exceed federally insured limits. The Company has not experienced any losses on these accounts. For the years ended December 31, 2021 and 2020, two partners represented approximately 73% and 77% of technology development revenue, respectively. As of December 31, 2021, four partners represented approximately 84% of total receivables under technology development arrangements. As of December 31, 2020, one partner represented approximately 93% of total receivables under technology development arrangements. The Company purchases from and relies on two vendors for specific equipment and consumables which are critical to its operations. While there are alternative types of equipment that could be used, switching vendors would require significant capital investment, long lead times and significant training and validation. Supplies Supplies, comprised principally of supplies and other materials used in the lab, are stated at the lower of cost or net realizable value and using the first-in, first-out method, applied on a consistent basis. The supplies inventory is included in prepaid expenses and other current assets on the consolidated balance sheet. Property and equipment, net Property and equipment are stated at cost less accumulated depreciation and amortization. Additions and improvements to property and equipment are capitalized. The costs of maintenance and repairs are expensed as incurred. Depreciation and amortization are computed using the straight-line method over the estimated useful lives of the underlying assets, which vary from 3 to 7 years. Leasehold improvements are amortized over the shorter of the term of the lease or the estimated useful lives of the assets. When assets are sold or otherwise disposed of, the cost and related accumulated depreciation or amortization are removed from their respective accounts, and the resulting gain or loss is reported as income or expense in the consolidated statements of operations and comprehensive loss. Impairment of long-lived assets Management reviews long-lived assets for possible impairment whenever events or circumstances indicate that the carrying amount of such assets may not be recoverable. Recoverability is measured by comparison of the carrying amount to the future undiscounted net cash flows expected to result from the use of the asset and its eventual disposition. If these estimated cash flows were less than the carrying amount of the asset, an impairment loss would be recognized in order to write down the asset to its estimated fair value. During the year ended December 31, 2021, the Company recognized $0.6 million in impairment expense of certain operating lease right-of-use assets and $0.3 million in impairment of leasehold improvements, resulting from the discontinued use of certain leased facilities. There were no such impairments of long-lived assets during the year ended December 31, 2020. Goodwill Goodwill is evaluated for impairment on an annual basis as of October 1, or more frequently if an indicator of impairment is present. As part of the impairment evaluation, the Company may elect to perform an assessment of qualitative factors. If this qualitative assessment indicates that it is more likely than not that the fair value of the reporting unit that includes the goodwill is less than its carrying value, then a quantitative impairment test would be prepared to compare this fair value to the carrying value and record an impairment charge if the carrying value exceeds the fair value. Redeemable convertible preferred units and stock warrant liability Outstanding warrants that were related to the Company’s redeemable convertible preferred units and redeemable convertible preferred stock were classified as liabilities on the consolidated balance sheets. As the warrants were exercisable for redeemable convertible preferred units and redeemable convertible preferred stock, the Company has recognized a liability for the fair value of its warrants on the consolidated balance sheets upon issuance and subsequently remeasures the liability to fair value at the end of each reporting period until the earlier of the expiration or exercise of the warrants. See Note 9: Redeemable convertible preferred stock for further discussion. Revenue recognition The Company recognizes revenue as control of its products and services are transferred to its customers in an amount that reflects the consideration expected to be received in exchange for those products and services. This process involves identifying the contract with a customer, determining the performance obligations in the contract, determining the contract price, allocating the contract price to the distinct performance obligations in the contract, and recognizing revenue when or as the performance obligations are satisfied. A performance obligation is considered distinct from other obligations in a contract when it provides a benefit to the customer either on its own or together with other resources that are readily available to the customer and is separately identified in the contract. The Company considers a performance obligation satisfied once control of a good or service has been transferred to the customer, meaning the customer has the ability to use and obtain the benefit of the good or service. Technology development revenue includes revenue associated to the development and technology readiness phases of technology development agreements. The Company refers to its customers as “partners” when describing their relationship in an agreement. Technology development revenue The Company’s Technology Development Agreements (“TDAs”) generally include multiple phases of drug discovery and/or Cell Line Development (“CLD”) such as library design, assay development, strain screening, fermentation optimization, purification, and analytics that all represent a single performance obligation. These agreements may include options for additional goods and services such as readying the technology to transfer to the partner and licensing terms. The transaction prices for these arrangements include fixed and variable consideration for the single performance obligation as well as variable consideration for success-based achievements. Any variable consideration is constrained to the extent that it is probable that a significant reversal of cumulative revenue will not occur. Depending on the specific terms of the arrangement, the Company either recognizes revenue over time or at a point in time. While there is no alternative use to the Company for the asset created, the agreement’s terms vary as to whether an enforceable right to payment exists for performance completed as of that date. Primarily all of the Company’s contracts with its partners include an enforceable right to payment. The Company measures progress toward the completion of the performance obligations satisfied over time using an input method based on an overall estimate of the effort incurred to date at each reporting period to satisfy a performance obligation. This method provides an appropriate depiction of completed progress toward fulfilling its performance obligations for each respective arrangement. In certain technology development agreements that require a portion of the contract consideration to be received in advance at the commencement of the contract, such advance payment is initially recorded as a contract liability. KBI BioPharma, Inc. Collaboration agreement In December 2019, the Company executed a four-year Joint Marketing Agreement (“JMA”) with KBI BioPharma, Inc. (“KBI”) to co-promote technologies through joint marketing efforts. The JMA provides for a non-refundable upfront payment of $0.8 million and milestone payments of $2.8 million in the aggregate, of which $2.3 million had been received as of December 31, 2021, upon the achievement of specific milestones. Upfront payments that relate to ongoing collaboration efforts required throughout the contract term such as joint marketing are recognized ratably throughout the contract term. The Company fully constrains revenue associated with the milestone payments until the specified milestones are probable of achievement. Additionally, KBI is obligated to make royalty payments to the Company during the fourth year of the JMA representing a percentage of its sales generated through the arrangement. Any costs incurred to KBI through the duration of the JMA are recognized as a reduction to collaboration revenue in the period in which they are incurred. In September 2021, the JMA was amended to shorten the term to approximately three years, while all remaining payments, including potential royalty payments, were replaced with a one-time fee due from KBI in the amount of $0.3 million. The Company determined the remaining services were distinct from those provided prior to the modification and therefore recognizes the total remaining transaction price prospectively over the remaining contractual term. As of December 31, 2021 and December 31, 2020, deferred revenue related to the JMA was $1.2 million and $1.8 million, respectively. Contract balances Contract assets are generated when contractual billing schedules differ from revenue recognition timing and the Company records a contract receivable when it has an unconditional right to consideration. As of December 31, 2021 and December 31, 2020, contract assets were $0.6 million and $0.1 million, respectively. Contract liabilities are recorded in deferred revenue when cash payments are received or due in advance of the satisfaction of performance obligations. As of December 31, 2021 and December 31, 2020, contract liabilities were $1.4 million and $2.6 million, respectively. During the years ended December 31, 2021 and 2020, the Company recognized $1.5 million and $0.2 million, respectively, as revenue that had been included in deferred revenue at the beginning of the period. Income taxes Prior to the LLC Conversion, all income tax effects of the Company's operations were passed through to its members individually. Accordingly, the accompanying financial statements do not include any income tax effects for the Company prior to the LLC Conversion date, and the Company had no unrecognized income tax benefits, nor any interest or penalties associated with unrecognized income tax benefits, accrued or expensed as of and for the period from January 1, 2020 through October 15, 2020. Following the LLC Conversion, the Company accounts for income taxes using the asset and liability method whereby deferred tax asset and liability accounts are determined based on differences between financial reporting and tax bases of assets and liabilities and are measured using the enacted tax rates and laws that are currently in effect. Valuation allowances are established where necessary to reduce deferred tax assets to the amounts expected to be realized. The Company files income tax returns in the federal and various state tax jurisdictions. The Company recognizes interest and penalties related to income tax matters as a component of tax expense. The Company did not record any interest or penalties related to income tax during the years ended December 31, 2021 and 2020. Leases At the inception of a contractual arrangement, the Company determines whether the contract contains a lease by assessing whether there is an identified asset and whether the contract conveys the right to control the use of the identified asset in exchange for consideration over a period of time. If both criteria are met, the Company records the associated lease liability and corresponding right-of-use asset upon commencement of the lease using the implicit rate or a discount rate based on a credit adjusted secured borrowing rate commensurate with the term of the lease. The Company additionally evaluates leases at their inception to determine if they are to be accounted for as an operating lease or a finance lease. Operating lease assets represent a right to use an underlying asset for the lease term and operating lease liabilities represent an obligation to make lease payments arising from the lease. Operating lease obligations with a term greater than one year and their corresponding right-of-use assets are recognized on the consolidated balance sheet at the commencement date of the lease based on the present value of lease payments over the expected lease term. Certain adjustments to the right-of-use asset may be required for items such as initial direct costs paid or incentives received. As the Company’s operating leases do not typically provide an implicit rate, the Company utilizes the appropriate incremental borrowing rate, determined as the rate of interest that the Company would have to pay to borrow on a collateralized basis over a similar term and in a similar economic environment. The lease cost is recognized on a straight-line basis over the lease term and variable lease payments are recognized as operating expenses in the period in which the obligation for those payments is incurred. Variable lease payments primarily include common area maintenance, utilities, real estate taxes, insurance and other operating costs that are passed on from the lessor in proportion to the space leased by the Company. The Company accounts for its finance leases by calculating an implied interest rate in the lease contract and recognizing a finance lease right of use asset and lease liability. The right of use asset is recognized in property and equipment, net, in the asset category in which the underlying asset relates. The lease liability is recognized in the consolidated balance sheet as a finance lease obligation. Research and development expenses Research and development expenses include the cost of materials, personnel-related costs (comprised of salaries, benefits and share-based compensation), consulting fees and allocated facility costs associated with both the Company’s execution of technology development agreements and collaboration agreements, as well as ongoing development of the Integrated Drug Creation Platform and other technologies. Allocated facility costs include facility occupancy and information technology costs. The Company derives improvements to its platform from both types of activities. The Company has not historically tracked its research and development expenses on a partner-by-partner basis or on a program-by-program basis. Stock-based compensation Stock-based compensation includes compensation expense for incentive units, restricted stock, and stock option grants to employees and is measured on the grant date based on the fair value of the award and recognized on a straight-line basis over the requisite service period. The fair value of options to purchase common stock are measured using the Black-Scholes option-pricing model. The Company accounts for forfeitures as they occur. Prior to the LLC Conversion, the Company also granted phantom units which due to the presence of an exercise condition contingent upon a liquidity event, the Company determined that it was not probable that the phantom units would become exercisable. Net Loss Per Share Attributable to Common Stockholders and Unitholders Basic and diluted net loss per common share is calculated by dividing net loss by the weighted-average number of common shares outstanding during the period, without consideration for common stock equivalents. The Company was in a loss position for all periods presented, therefore basic net loss per share and diluted net loss per share are the same for all periods as the inclusion of all potential common securities outstanding would have been anti-dilutive. Recently adopted accounting pronouncements In August 2020, the FASB issued ASU No. 2020-06, Debt — Debt with Conversion and Other Options (Subtopic 470-20) and Derivatives and Hedging — Contracts in Entity’s Own Equity (Subtopic 815-40) (“ASU No. 2020-06”). The new guidance eliminates two of the three models in ASC 470-20 that require separating embedded conversion features from convertible instruments. As a result, only conversion features accounted for under the substantial premium model in ASC 470-20 and those that require bifurcation in accordance with ASC 815-15 will be accounted for separately. For contracts in an entity’s own equity, the new guidance eliminates some of the requirements in ASC 815-40 for equity classification. The guidance also addresses how convertible instruments are accounted for in the diluted earnings per share calculation and requires enhanced disclosures about the terms of convertible instruments and contracts in an entity’s own equity. ASU 2020-06 is effective for the Company after December 15, 2023. Early adoption is permitted for fiscal periods beginning after December 15, 2020. The Company adopted this standard as of January 1, 2021, and the adoption of this standard did not have a material impact on its consolidated financial statements. Recently issued accounting pronouncements, not yet adopted In December 2019, the FASB issued amended guidance on the accounting and reporting of income taxes. The guidance is intended to simplify the accounting for income taxes by removing exceptions related to certain intraperiod tax allocations and deferred tax liabilities; clarifying guidance primarily related to evaluating the step-up tax basis for goodwill in a business combination; and reflecting enacted changes in tax laws or rates in the annual effective tax rate. The amended guidance is effective for fiscal years beginning after December 15, 2021, and interim periods within fiscal years beginning after December 15, 2022. Early adoption is permitted. The application of the amendments in the new guidance are to be applied on a retrospective basis, on a modified retrospective basis through a cumulative-effect adjustment to retained earnings or prospectively, depending on the amendment. The Company is currently evaluating the impact of the potential adoption of this guidance on its consolidated financial statements.

Fair Value Measurements - Assets and Liabilities Measured on Recurring Basis (Details) - Fair Value, Recurring - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020
Assets:
Equity securities without RDFV	$ 1,200
Total assets	1,200
Liabilities:
Fee in-lieu of warrant		$ 22
Preferred stock warrant liability		698
Contingent consideration	12,000
Total liabilities	12,000	720
Level 1
Assets:
Equity securities without RDFV	0
Total assets	0
Liabilities:
Fee in-lieu of warrant		0
Preferred stock warrant liability		0
Contingent consideration	0
Total liabilities	0	0
Level 2
Assets:
Equity securities without RDFV	0
Total assets	0
Liabilities:
Fee in-lieu of warrant		0
Preferred stock warrant liability		0
Contingent consideration	0
Total liabilities	0	0
Level 3
Assets:
Equity securities without RDFV	1,200
Total assets	1,200
Liabilities:
Fee in-lieu of warrant		22
Preferred stock warrant liability		698
Contingent consideration	12,000
Total liabilities	$ 12,000	$ 720

Stock-based compensation

12 Months Ended

Dec. 31, 2021

Share-based Payment Arrangement [Abstract]

Stock-based compensation

Prior to the LLC Conversion, the Company granted incentive units and phantom units under its 2015 Equity-Based Incentive Plan (“2015 Plan”) to employees and non-employee service providers. In October 2020, in conjunction with the LLC Conversion, the Company adopted the 2020 Stock Option and Grant Plan (“2020 Plan”) under which it granted stock options, restricted shares, and SARs as replacement awards for outstanding awards under the 2015 Plan and as new awards to incentivize employee service. Upon completion of the IPO, the Company adopted the 2021 Stock Option and Incentive Plan (“2021 Plan”).

Total stock-based compensation expense related to all of the Company’s stock-based awards was recorded in the consolidated statements of operations and comprehensive loss as follows (in thousands):



	For the Years Ended December 31,
		2021		2020
Research and development		4,637		188
Selling, general and administrative		5,971		232
Total stock-based compensation expense		$	10,608	$	420

Restricted Stock

Upon the LLC Conversion, the outstanding 3,329,707 incentive units were exchanged for 2,671,907 restricted shares of common stock granted under the 2020 Plan based on a ratio determined by their threshold amount and the fair value of the restricted stock. The exchange was accounted for as a probable-to-probable modification (Type I modification), and the fair value of the restricted shares did not exceed the fair value of the incentive units on the date of exchange. Accordingly, the restricted shares are measured at the grant date fair value of the incentive units. Shares of restricted stock that do not vest are subject to our right of repurchase or forfeiture. In connection with its acquisitions of Denovium and Totient, the Company issued restricted shares of common stock that vest over time subject to continued service.

Activity for the restricted shares is shown below:


			Number of shares
Unvested as of December 31, 2020			1,111,642
Granted			2,441,129
Vested			(967,101)
Unvested as of December 31, 2021			2,585,670

As of December 31, 2021, there was $11.5 million of unrecognized compensation expense related to the restricted shares expected to be recognized over a remaining weighted-average period of 2.6 years.

Phantom Units

Phantom units generally vested at 25% after one-year with the remainder vesting quarterly over the following three-year period. Upon the occurrence of a liquidity event, 100% of phantom units would vest. A liquidity event for purposes of the phantom units meant either of the following events: (i) a person or persons acting as a group (other than a person or group that currently owns more than 50% of the voting power of the Company) acquires ownership of common units that, together with the common units held by such person or group, constitutes more than 50% of the voting power of all common units of the Company or (ii) a person or persons acting as a group acquires (or has acquired during the 12-month period ending on the date of the most recent acquisition by such person or persons) assets from the Company that have a total gross fair market value of more than 60% of the total gross fair market value of all of the assets of the Company immediately before such acquisition or acquisitions. Upon a liquidity event, the phantom unit holders were entitled to a payment equal to the fair value of common units less a strike price. The payment was to be made in the same form of consideration as received by other unit holders as a result of the liquidity event. Other than this payment upon a liquidity event, phantom units provided no economic value and they provided no voting rights. Due to the presence of an exercise condition that was contingent upon a liquidity event, the Company determined that it was not probable that the phantom units would become exercisable and no compensation expense has been recognized.

Activity for the phantom units is shown below:


	Number of Units	Weighted Average Strike Price
Unvested as of December 31, 2020	1,202,435	$	0.47
Granted	—	—
Vested	—	—
Exchange of Phantom Units for Cash Payment Rights, SARs, and/or Stock Options	(1,202,435)	$	0.47
Unvested as of December 31, 2021	—	$	—

Following the LLC Conversion, the holders of phantom units were offered to exchange their awards for a combination of cash payment rights, SARs and/or stock options granted under the 2020 Plan. The exchange was accounted for as short-term inducement, with no accounting recognition prior to offer expiration in January 2021 as the exchange offer participants were able to modify their election through the expiration date. In January 2021, all participants accepted the offer. The exercisability of the SARs is contingent upon a liquidity event that is not probable of occurrence; accordingly, no compensation expense has been recognized for these awards. The stock options vest based on a service condition, generally over a 4-year term beginning with the vesting commencement date of the exchanged phantom units.

The aggregate intrinsic value of the 394,736 SARs outstanding as of December 31, 2021 is $3.2 million based on the estimated fair value of common stock of $8.20.

Stock Options

Stock options generally vest 25% after one-year from the date of the grant with the remainder vesting monthly over the following three-year period. Certain options have alternative vesting schedules including ratably over 2-4 years and immediate vesting. The Company recognizes forfeitures as they occur, and uses the straight-line expense recognition method. Activity for stock options is shown below:


	Number of Options	Weighted Average Exercise Price per Share		Weighted Average Remaining Contractual Term (in years)	Aggregate Intrinsic Value (in thousands $)
Outstanding at December 31, 2020	1,706,339	$	1.10	9.8	$	780
Granted	7,386,667	4.01			—
Exercised	(153,416)	1.10
Canceled/ Forfeited	(1,182,189)	2.14			—
Outstanding at December 31, 2021	7,757,401	3.72		9.2	40,939
Exercisable at December 31, 2021	1,675,979	$	1.13	9.0	$	11,851
Vested and expected to vest as of December 31, 2021	7,757,401			9.2	$	40,939

The aggregate intrinsic value was calculated based on the estimated fair value of common stock of $8.20 per share.

The weighted-average grant date fair value of stock options granted during the years ended December 31, 2021 and 2020 was $4.28 and $0.83, respectively. The fair value of options vested during the years ended December 31, 2021 and 2020 was $2.4 million and $0.1 million, respectively. The intrinsic value of options exercised, which represents the value of the Company’s common stock at the time of exercise in excess of the exercise price, was $1.4 million during the year ended December 31, 2021. As of December 31, 2021, total unrecognized stock-based compensation related to stock options was $24.6 million, which the Company expects to recognize over a remaining weighted average period of 3.4 years.

Under the 2020 Plan and 2021 Plan, the Company has also granted a limited quantity of cash-settled stock appreciation rights to certain international-based employees and consultants. As of December 31, 2021, 100,881 of these stock appreciation rights were outstanding with a weighted average exercise price of $4.97. As of December 31, 2021, the Company had recognized a liability of $0.1 million classified within other long-term liabilities on the consolidated balance sheets and total unrecognized stock-based compensation related to these cash-settled stock appreciation rights was $0.7 million, which the Company expects to recognize over a remaining weighted average period of 3.5 years.

Determination of Fair Value

The estimated grant-date fair value of all the Company’s stock options was calculated using the Black-Scholes option pricing model, based on the following assumptions:



	For the Years Ended December 31,
	2021	2020
Expected term (in years)	3.5-6.1	2.0-6.0
Volatility	45%-47%	45%-85%
Risk-free interest rate	0.3%-1.5%	0.1%-1.6%
Dividend Yield	—%	—%

The fair value of each stock option was determined by the Company using the methods and assumptions discussed below. Each of these inputs is subjective and generally requires significant judgment and estimation by management.

Expected Term—The expected term represents the period that stock-based awards are expected to be outstanding. The Company’s stock options do not have a contractual term. However, there is a constructive maturity of each stock option based on the expected exit or liquidity scenarios for the Company. The Company’s historical option exercise data is limited and did not provide a reasonable basis upon which to estimate an expected term. The expected term for options was derived by using the simplified method which uses the midpoint between the average vesting term and the contractual expiration period of the stock-based award.

Expected Volatility—As we do not have sufficient trading history for our common stock, the expected volatility was derived from the historical stock volatilities of comparable peer public companies within the Company’s industry. These companies are considered to be comparable to the Company’s business over a period equivalent to the expected term of the stock-based awards.

Risk-Free Interest Rate—The risk-free interest rate is based on the U.S. Treasury yield curve in effect at the date of grant for zero-coupon U.S. Treasury notes with maturities approximately equal to the stock options’ expected term.

Expected Dividend Rate—The expected dividend is zero as the Company has not paid nor does it anticipate paying any dividends on its common stock underlying its stock options in the foreseeable future.

The Company estimated the fair value of its common stock underlying the stock-based awards when performing fair value calculations using the Black-Scholes option pricing model. Because the Company’s common stock was not publicly traded during the periods prior to the IPO, the fair value of its common stock underlying the stock-based awards was determined on each grant date by management and approved by the Board, considering the most recently available third-party valuation of the Company’s common stock for those periods. For all grants subsequent to the IPO, the fair value of common stock was determined by using the closing price per share of common stock as reported on the Nasdaq Global Select Market. All options to purchase shares of the Company’s common stock are intended to be granted with an exercise price per share no less than the fair value per share of the common stock underlying those options on the date of grant, based on the information known to the Company on the date of grant.

The Company’s determination of the value of its common stock was performed using methodologies, approaches and assumptions consistent with the American Institute of Certified Public Accountants (“AICPA”), Audit and Accounting Practice Aid Series: Valuation of Privately Held Company Equity Securities Issued as Compensation (“AICPA Practice Aid”). In addition, the Board considered various objective and subjective factors to determine the fair value of the common stock, including:

•valuations of the Company’s common stock performed by third-party valuation specialists;

•the anticipated capital structure that will directly impact the value of the currently outstanding securities;

•the Company’s results of operations and financial position;

•the composition of, and changes to, the management team and board of directors;

•the lack of liquidity of the Company’s common stock as a private company;

•the Company’s stage of development and business strategy and the material risks related to its business and industry;

•external market conditions affecting the life sciences and biotechnology industry sectors;

•U.S. and global economic conditions;

•the likelihood of achieving a liquidity event for the holders of the Company’s common stock, given prevailing market conditions; and

•the market value and volatility of comparable companies.

The AICPA Practice Aid prescribes several valuation approaches for setting the value of an enterprise, such as the cost, income and market approaches, and various methodologies for allocating the value of an enterprise to its common stock. The cost approach establishes the value of an enterprise based on the cost of reproducing or replacing the property less depreciation and functional or economic obsolescence, if present. The income approach establishes the value of an enterprise based on the present value of future cash flows that are reasonably reflective of our future operations, discounting to the present value with an appropriate risk adjusted discount rate or capitalization rate. The market approach is based on the assumption that the value of an asset is equal to the value of a substitute asset with the same characteristics.

In accordance with the AICPA Practice Aid, the Company considered the various methods for allocating the enterprise value to determine the fair value of its common stock at the valuation date. Under the option pricing method (“OPM”), shares are valued by creating a series of call options with exercise prices based on the liquidation preferences and conversion terms of each equity class. The value of the common stock is inferred by analyzing these options. The probability weighted expected return method (“PWERM”) is a scenario-based analysis that estimates the value per share based on the probability-weighted present value of expected future investment returns, considering each of the possible outcomes available to us, as well as the economic and control rights of each share class.

Starting in 2020 and until the IPO in July 2021, the Company used a hybrid method to determine the estimated fair value of its common stock, which included both the OPM and PWERM models.

In June 2021, the Company increased the number of shares of common stock reserved for future issuance under the 2020 Plan to 11,980,029. In July 2021, upon the completion of IPO, the Company adopted the 2021 Plan. The number of shares of common stock initially reserved for future issuance under the 2021 Plan is 8,133,750. As of December 31, 2021, 7,473,403 shares were available for issuance under the 2021 Plan.

Employee Stock Purchase Plan

In July 2021, the Company’s board of directors adopted the 2021 Employee Stock Purchase Plan (“2021 ESPP”), which was subsequently approved by the Company’s stockholders and became effective in connection with the IPO. A total of 903,750 shares of common stock were reserved for issuance under the 2021 ESPP. The first offering period has not commenced as of December 31, 2021 and there is no stock-based compensation related to the 2021 ESPP for the period ended December 31, 2021.